Josiah, According to the MySQL docs at http://www.mysql.com/documentation/mysql/bychapter/ (See "1.2.4 How big can MySQL tables be?") MySQL tables by default have a maximum size of "about 4 GB". You can check this using the "SHOW TABLE STATUS" command. If you're trying to load all of GenBank, or even all of the EST division, it wouldn't surprise me if you exceeded 4 GB in one or more tables. -- Tim