[Biopython-dev] Bio.SeqUtils.MeltingTemp Tm_staluc does not accept sequence object

Markus Piotrowski Markus.Piotrowski at ruhr-uni-bochum.de
Sat Dec 17 22:33:20 UTC 2011

Dear Biophython developers,

It seems that modul Tm_staluc from Bio.SeqUtils does not accept sequence objects
as input but 'just' strings.

I think that is somewhat unusal for a 'SeqUtil', shouldn't sequence utilities
accept sequence objects?

I also think that the modul name 'Tm_staluc' is not self-explanatory. Obviously
the name is derived from the corresponding author of the paper which describes
this Tm calculation, SantaLucia. The method is better known (and described so in
the documentation) as nearest neighbor thermodynamics, so it would better be
called something like Tm_nn (nearest neighbor). However, taking into
consideration that more Tm methods will be added in future, they may just be

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