I have made available for testing Bio::Microarray support for Affy and GEO XML and MINiML formats. The next step will be support for RMA and quantile normalisation. See: http://github.com/pjotrp/bioruby/tree/master http://github.com/pjotrp/bioruby/tree/master/lib/bio/db/microarray git://github.com/pjotrp/bioruby.git Enjoy, Pj.