Hi Tim, check tutorials and bioruby related materials on these blogs: http://www.biorelated.wordpress.com http://www.bioinformaticszen.com/ http://saaientist.blogspot.com/ http://bioinforuby.blogspot.com/ http://rubyonwindows.blogspot.com/ http://bioruby.g.hatena.ne.jp/nakao_mitsuteru/