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<title>ISC Laboratory Instrumentation News : Newsletter February 2004</title>
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<td bgcolor="#ffffff" colspan=2><p><STRONG><EM>Laboratory Instrumentation
News</EM></STRONG> is published by International Scientific
Communications, Inc., the publisher of <STRONG><EM>American
Laboratory</EM></STRONG> and <STRONG><EM>American Biotechnology
Laboratory,</EM></STRONG> your up-to-date source for industry news,
information on new products, and links to authoritative technical articles
and application notes. You are receiving this e-mail newsletter free of
charge as a subscriber to one of our publications. We hope you will find
the information provided in this e-newsletter interesting and informative.
If you prefer not to receive <STRONG><EM>Laboratory Instrumentation
News,</EM></STRONG>
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<font color=#990000> <b>In this February 2004 issue</b></font>
<UL>
<li type=disc><A style="COLOR: #990000" href="#f1">Industry News: Shimadzu announces a worldwide OEM distribution agreement</A></li>
<li type=disc><A style="COLOR: #990000" href="#f2">Industry News: Burrill & Co. ends strong fiscal year</A></li>
<li type=disc><A style="COLOR: #990000" href="#f3">Article: Statistics in Analytical Chemistry</A></li>
<li type=disc><A style="COLOR: #990000" href="#f4">Industry News: Affymetrix, Inc. and Caliper Technologies Corp. join forces</A></li>
<li type=disc><A style="COLOR: #990000" href="#f5">Article: Dual pH extraction of 8270 Semi-volatiles from Aqueous Samples by Fast
Automated SPE</A></li>
<li type=disc><A style="COLOR: #990000" href="#f6">Industry News: Innovative Biosensors to develop SARS test</A></li>
<li type=disc><A style="COLOR: #990000" href="#f7">Industry News: Charles River Laboratories International, Inc. acquires River Valley Farms</A></li>
<li type=disc><A style="COLOR: #990000" href="#f8">Article: A Dynamic In Vivo Surrogate Assay Platform for Cell-Based Studies</A></li>
<li type=disc><A style="COLOR: #990000" href="#f9">Industry News: Bruker BioSpin Corp. opens a completely redesigned U.S. headquarters facility</A></li>
<li type=disc><A style="COLOR: #990000" href="#f10">Industry News: Tetracore, Inc. receives 510(K) clearance</A></li>
<li type=disc><A style="COLOR: #990000" href="#f11">Article: Sizing Up Nanotechnology</A></li>
</UL>
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<b><i>
Lachat Instruments - QuikChem<small><sup>®</sup></small> 8500 </i></b>
</FONT></center>
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<p>
Lachat Instruments, the Proven Leader in Automated Ion Analysis, is pleased to offer a total solution to your laboratory analysis needs. The QuikChem<small><sup>®</sup></small> 8500 is the latest update to Lachat's flagship ion analyzer system. The proven productivity of FIA combined with the outstanding accuracy, precision, minimum detection limits, and dynamic ranges of our guaranteed QuikChem<small><sup>TM</sup></small> methods and unique Data Quality Management<small><sup>TM</sup></small> closed-loop software offer fast, accurate results. </p>
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<tr><td colspan=3> For laboratories requiring high sample/analyte variation in their environmental analysis, Lachat's new AP300 discrete analyzer offers simplified analysis with reliable results. Low reagent consumption and reduced daily start-up times translate into substantial cost savings for laboratories. The AP300 boasts several advantages over its competitors, including 16 standard positions and two pipettes to reduce cross-contamination.
<br><BR>
For both new instruments, Lachat is pleased to announce its new prepared reagents, which will help customers save time and money while guaranteeing the integrity and quality of results.
<br><BR>
With Lachat, the customer can expect superior service and technical support, as well as a large breadth of applications. For more information about these and other Lachat products, or to learn more about which technology best suits your laboratory needs, call 800-247-7613 or <A href="http://pull.xmr3.com/p/8269-04C6/81677189/pull1.html">Click here to read more</A>.
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<td bgcolor="#990000"><a name="f1"></a><center>
<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Shimadzu announces a worldwide OEM distribution agreement </i></b></FONT> </center></td>
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<p>
<strong>Shimadzu Corp.</strong> has announced a worldwide OEM distribution agreement with <strong>Nonlinear Dynamics</strong>, a leading provider of bioinformatics software solutions. Under the terms of the agreement, <strong>Shimadzu Biotech</strong> will distribute a dual-branded version "Shimadzu Phoretix" of a selection of Nonlinear's software solutions. The products are for the analysis and data mining of 2-D and 1-D electrophoresis gels, the core separation technologies for proteomics and genomics research. </p>
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<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3>
<b><i>
UV-Vis Spectrophotometers from Shimadzu </i></b>
</FONT></center>
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<I>Advertisement</I></center>
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<p>
Shimadzu meets your needs for ruggedness, ease of use, validation and applications with a wide range of UV-Vis spectrophotometers. Choose from the easy-to-use UV-Mini, the bioscience-oriented Bio-Mini, the rugged UV-1650PC, or the UV-1700 – designed to meet your compliance needs. Other models include the single monochromator UV-2401PC, the double-blazed, double monochromator UV-2501PC, and the UV-3101PC, which combines research-grade optical performance in the UV-Vis-NIR with the ease and familiarity of the Windows platform. Visit our Web site for more information.
<br>
<br>
Shimadzu Scientific Instruments
<br>Tel.: 800-477-1227
<br>
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<td bgcolor="#990000"><a name="f2"></a><center>
<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Burrill & Co. ends strong fiscal year </i></b></FONT> </center></td>
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<p>
San Francisco-based life sciences merchant bank <strong>Burrill & Co.</strong> announced that the year ended on a very sound footing. The industry generated record revenues in 2003 and broke all records for government funding allocations. Seven companies went public, raising $453 million. Fourteen additional deals were on file, with three having been pulled. Many have products in late-stage clinical trials and some are already generating significant revenues. All six companies that filed in December were aimed at product development. </p>
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<b><i>
Drying Equipment Catalog </i></b>
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<p>
A catalog describes desiccants and related drying equipment for drying solids, liquids, and gases for protecting equipment and materials from the effects of moisutre. Included are gas dryers, gas purifiers, balance desiccators, vent dryers for bulk storage, and desiccant bags.
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Tel.: (937) 376 - 2927<br>
Fax.: (937) 376 - 1977<br>
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<td valign=top align=justify><a name="f4"></a>
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<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Statistics in Analytical Chemistry </i></b></FONT> </center></td>
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<td valign=top align=justify>
<p>
This series of
articles by David Coleman and Lynn Vanatta covers a selection of topics in basic statistics for laboratory scientists. Everyone will benefit from reviewing these contributions, whether you are an experienced professional, laboratory technician, or student.
<br><br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677201/pull5.html">Part 1: A new American Laboratory column</A><br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677291/pull6.html">Part 2: Measurement and the real-number line</A> <br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677293/pull7.html">Part 3: Calibration—Introduction and ordinary least squares</A> <br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677297/pull8.html">Part 4: Calibration: Uncertainty intervals </A><br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677299/pull9.html">Part 5: Calibration: Calibration design </A><br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677301/pull10.html">Part 6: Calibration design </A><br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677394/pull11.html">Part 7: A Review</A><br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677396/pull12.html">Part 8: Calibration Diagnostics</A><br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677400/pull13.html">Part 9: Calibration Diagnostics (continued)</A>
</p>
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<b><i>
Laboratory Balances from Sartorius </i></b>
</FONT></center>
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<p>
CP Series from Sartorius Excellent performance. Exceptional value.</h5><p> The CP Series of
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<td bgcolor="#990000"><a name="f4"></a><center>
<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Affymetrix, Inc. and Caliper Technologies Corp. join forces </i></b></FONT> </center></td>
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<p>
<strong>Affymetrix, Inc.</strong> and <strong>Caliper Technologies Corp.,</strong> now doing business as <strong>Caliper Life Sciences,</strong> have announced a collaboration and supply agreement to develop and provide automated target preparation instruments for the GeneChip<sup><small>®</small></sup> probe array system, the High-Thoughput Array (HTA) system, and future GeneChip platforms. The automated systems are expected to substantially reduce array processing time, reduce variability and labor costs, and enable researchers to industrialize their genomic research. Affymetrix will market and distribute the line of automation products developed under the agreement. Caliper will serve as an OEM provider and partner with Affymetrix to provide installation, training, and field support for the automated systems. </p>
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<b><i>
Ultrasonic Processors </i></b>
</FONT></center>
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</td>
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<p>
The VCX line of Ultrasonic Processors by Sonics sets the standard as the most productive and advanced in the industry.
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<li type=disc>Microprocessor Based</li>
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Typical applications include: Cell disruption, sample prep, dissolution, and homogenization. Free tapered microtip with system purchases by 6/30/04.
<strong>Not all Ultrasonic Processors are created equal. The VCX is different.</strong>
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Contact Sonics at 1-800-452-6788 or
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<td bgcolor="#990000"><a name="f5"></a><center>
<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Dual pH extraction of 8270 Semi-volatiles from Aqueous Samples by Fast
Automated SPE. </i></b></FONT> </center></td>
</tr>
<tr>
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<p>
The purpose of this document is to demonstrate the use of fastautomated
SPE techniques for 8270 semi-volatile compounds from
aqueous samples. The procedures fall under the guideline
described in EPA Method 3535A Solid Phase Extraction.<br><br>
The Horizon DryDisk™ provides a fast easy alternative to sodium
sulfate drying columns. It consists of a patented Gore-Tex®
membrane filter that allows the organic layer (DCM and analytes)
to pass through the membrane while retaining residual water from
the SPE disk.
<br><br><A href="http://pull.xmr3.com/p/8269-04C6/81677405/pull15.html">Click here to read more</A>.
</p>
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<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3>
<b><i>
CAMBRIDGE APPLIED SYSTEMS (CAS) ANNOUNCES THE VISCOLAB 450 for LABORATORY VISCOSITY MEASUREMENTS </i></b>
</FONT></center>
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<I>Advertisement</I></center>
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<p>
Cambridge Applied Systems, Inc. (CAS), a leading provider of solutions for viscosity measurements and control, announced the ViscoLab 450, a new tool for viscosity measurements in laboratory environments. The ViscoLab 450 is unique in that it accurately measures viscosity in one of ten ranges from 0.5 to 10,000 centipoise with an accuracy equal to ± 1 %. The basic system reads viscosity at ambient temperature and with the addition of a jacket for a re-circulating bath it can measure viscosities within a temperature range from –40 to + 110 °C.
Based on CAS's patented technology, the ViscoLab 450 has only one moving part, a stainless steel piston that is forced back and forth within a small measurement chamber. The piston is moved by electromagnetic force from coils inside the sensor body. Magnetic force on the piston is resisted by viscous flow of the fluid around the piston: the more viscous the fluid, the slower the piston's motion. Less than 1-1/2 mL fluid is required for an accurate reading, and the unit is simple to clean and maintain.<br><br>
Please visit us at PittCon booth <big>5115</big>.
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<td bgcolor="#990000"><a name="f6"></a><center>
<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Innovative Biosensors to develop SARS test </i></b></FONT> </center></td>
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<p>
<strong>Innovative Biosensors Inc.,</strong> a privately held pioneering developer of rapid diagnostic technologies, has entered into a cooperative research and development agreement with the U.S. Army Medical Research Institute of Infectious Disease for the development of a SARS test using the company's Canary<small><sup>TM</sup></small> technology. The agreement involves the development of a rapid, portable, and highly sensitive system for the detection of SARS. </p>
</td>
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<td bgcolor="#990000"><a name="f7"></a><center>
<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Charles River Laboratories International, Inc. acquires River Valley Farms </i></b></FONT> </center></td>
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<p>
<strong>Charles River Laboratories International, Inc.</strong> has acquired <strong>River Valley Farms,</strong> a privately held medical device contract research business focused on providing preclinical evaluation services to the medical device industry. Charles River Laboratories is a leading provider of critical research tools and integrated support services that enable innovative and efficient drug discovery and development. </p>
</td>
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<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3>
<b><i>
With Gradipore Precast Gels enjoy consistency and
increased resolution at an affordable price! </i></b>
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<p>
iGels are available in 8, 10, and 12% homogeneous gels and
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<td bgcolor="#990000"><a name="f8"></a><center>
<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>A Dynamic In Vivo Surrogate Assay Platform for Cell-Based Studies </i></b></FONT> </center></td>
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<p>
<center>by Gregory T. Baxter and Robert Freedman</center>
<br><br>
Traditional methods of predicting
human response to potential therapeutics
utilize surrogates: either in vitro
cell culture assays or in vivo animal
models. In vitro cell-based assays are
often of limited predictive relevancy
because they do not mimic with sufficient
realism the complex environment
to which a drug candidate is subjected
within a living organism. In vivo
animal studies can account for complex
intercellular and intertissue effects
not observable from in vitro tests, but
animal studies are expensive, labor
intensive, time consuming, and unpopular.
In addition, there is considerable
concern whether animal studies can
predict human risk precisely enough
because, first, there is no known mechanistic
basis for extrapolation to low doses, and second,
cross-species extrapolation has been found to be
frequently problematic with respect to toxicity
and pharmacokinetic characteristics.
<br><br><A href="http://pull.xmr3.com/p/8269-04C6/81677538/pull18.html">Click here to read more</A>.
</p>
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<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3>
<b><i>
PhyNexus Isolates and Studies Elusive Proteins </i></b>
</FONT></center>
</td>
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<I>Advertisement</I></center>
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<p>
PhyNexus, Inc., a pioneering Silicon Valley biotechnology firm, announces
the launch of their revolutionary PhyTip<small><sup>TM</sup></small> Columns for high speed micro volume scale protein purification. These products were developed to address
the specific need to overcome the bottleneck of efficient sample preparation
of small volumes in small to large numbers and produce high concentrations
of pure protein with retained functionality.
</p>
</td>
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PhyTip Columns are available in two standard formats for 200 µL or 1000 µL
sample volumes. With their unique proprietary design, each PhyTip Column
contains a specific affinity resin bed that is used to capture the protein
of interest. The trapped protein can then be washed and purified before
elution into a final volume of 10 µL - 20 µL, this final step producing
unsurpassed concentrations of up to 5 mg/mL of functionally active protein
in these micro volumes. This entire process of capture, purification and
enrichment can be completed in less than 10 minutes.
<br>
<br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677542/pull19.html">Click here to read more</A>
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<td bgcolor="#990000"><a name="f9"></a><center>
<FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Bruker BioSpin Corp. opens a completely redesigned U.S. headquarters facility </i></b></FONT> </center></td>
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<p>
<strong>Bruker BioSpin Corp.</strong> has opened a completely redesigned U.S. headquarters facility to provide state-of-the-art services for research and development, manufacturing, customer demonstrations, applications development, and customer training and support. Custom designed for the unique needs of the NMR and MRI division of the company, the facility offers improved research, manufacturing, and quality control capabilities for NMR products. A CryoProbe service and testing center enables faster and more efficient response to U.S. customers' service needs. </p>
</td>
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<b><i>
Gerstel: Extending Your GC Capability and Productivity </i></b>
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Gerstel offers effective GC and GC/MS solutions designed to optimize performance and extend capabilities for determining trace components in complex matrices. The Gerstel Twister® performs simplified extraction, enabling ultra-trace analysis of organic compounds. Gerstel Thermal Desorption Systems, including the new TDS-3, enable efficient transfer of analytes from gas, liquid, or solid samples, including higher molecular weight components. Gerstel's MPS2 MultiPurpose Samplers provide unparalleled versatility and productivity for automated GC sampling.
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Gerstel also offers cooled programmable temperature vaporization (PTV) inlets, olfactory detection ports, multidimensional GC column switching systems, and preparative fraction collectors.
<br><br>
Visit Gerstel at Pittcon, Booth 3488<br>
<br>
Gerstel, Incorporated<br>
1510 Caton Center Drive<br>
Baltimore, MD 21227<br>
Phone: 800-413-8160<br>
E-mail: <a href="mailto:Sales@gerstelus.com">sales@gerstelus.com</a><br>
<br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677547/pull20.html">Click here to read more</A>.
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<i>Tetracore, Inc. receives 510(K) clearance </i></b></FONT> </center></td>
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<strong>Tetracore, Inc.</strong> has received 510(K) clearance from the FDA for its Red-Line Alert antibody-based test kit for use as an aid in the clinical laboratory identification of <em>Bacillus anthracis</em> colonies from culture plates. The test is a lateral flow immunoassay containing a monoclonal antibody that is specific for the presence of a cell surface protein found in <em>Bacillus anthracis</em> vegetative cells. The test can be used on colonies as early as 12 hr old, and can be completed in 20 min. </p>
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<i>Sizing Up Nanotechnology </i></b></FONT> </center></td>
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<center>by Malcolm Connah</center>
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The explosion of interest in nanotechnology
and its potential applications has brought with
it many challenges in understanding and quantifying
the behavior of materials operating in a
nanoscale environment. Nanosize particles play
an important role in many areas, since it is possible
to change the properties of a material simply
by changing its size.
<br><br>
Ref. 1 discusses the application of nanoparticles
in such diverse areas as quantum dots for computer
memory enhancements, lightweight composites
for automotive and packaging materials,
sunscreens, coatings for lenses that make them
scratchproof and unbreakable, ski waxes, glues,
and electronic device casings that offer improved
shielding against electromagnetic radiation.
New composites and coatings are continually
being developed, and the pace of change is
being driven in part by the ability to construct
nanoparticles from many different materials
and, importantly, the ability to control their
size, composition, and consistency.
<br><br><A href="http://pull.xmr3.com/p/8269-04C6/81677580/pull21.html">Click here to read more</A>.
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<b><i>
Solver NTF from NTA- The Complete, multi-faceted SPM. </i></b>
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Which of the 40 different micro- and nano-measurements will solve your problem? In addition to conventional phase and topography images, NTF offers a constellation of physical (adhesion, friction, magnetism), electrochemical, and electrical (spreading resistance, Kelvin, capacitance) measurements. Nanotech ready, NTF does both nanolithography (scratching or voltage/oxidation) and nanomanipulation. Easy to use and easy to learn, its modular design allows you to start with a simple stand and build as your lab and requirements grow.
<br><br>
Contact: Barbara Foster, for Nanotech-America, Inc<br>
Barbara@nt-america.com<br>
P: 413-693-0010<br>
<A href="http://pull.xmr3.com/p/8269-04C6/81677584/pull22.html">Click here to read more</A>.
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