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<title>ISC Laboratory Instrumentation News : Newsletter January 2004</title>
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<td bgcolor="#ffffff" width="50%"><p><STRONG><EM>Laboratory Instrumentation
News</EM></STRONG> is published by International Scientific
Communications, Inc., the publisher of <STRONG><EM>American
Laboratory</EM></STRONG> and <STRONG><EM>American Biotechnology
Laboratory,</EM></STRONG> your up-to-date source for industry news,
information on new products, and links to authoritative technical articles
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<font color=#990000
> <b>In this January 2004 issue</b></font>
<UL>
<li type=disc><A style="COLOR: #990000" href="#f1">Industry News: Shimadzu Biotech and ISB join forces against disease</A>
<li type=disc><A style="COLOR: #990000" href="#f2">Industry News: ProMetic BioSciences helps to purify plasma for the Red Cross</A>
<li type=disc><A style="COLOR: #990000" href="#f3">Article: A Mass Spectrometry Detector Array That Provides Truly Simultaneous Detection </A>
<li type=disc><A style="COLOR: #990000" href="#f4">Industry News: SurroMed acquires Bruker Daltonics' mass spectrometers</A>
<li type=disc><A style="COLOR: #990000" href="#f5">Article: Rediscovering Polarized Light
Microscopy</A>
<li type=disc><A style="COLOR: #990000" href="#f6">Industry News: The Swiss approve Erbitux<sup><small>TM</small></sup> for cancer treatment</A>
<li type=disc><A style="COLOR: #990000" href="#f8">Industry News: Charles River Proteomic Services (CRPS) and CEM Corp. present a robust platform to enhance the identification of proteins</A>
</UL>
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i> UV-VIS Spectrophotometers from Shimadzu</i></b></FONT></center></td>
</tr>
<TR>
<td width="100%" valign=top colspan=2><center>
<I>Advertisement</I></center>
</td>
</TR>
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<td valign=top><IMG height=150 src="http://www.isc-newsletter.com/newsletter/jan04/lin/Shimadzu.jpg" border=0>
</td>
<td valign=top align=justify>
<p>  
Shimadzu meets your needs for ruggedness, ease of use, validation and applications with a wide range of UV-VIS spectrophotometers. Choose from the easy-to-use UV-Mini, the bioscience-oriented Bio-Mini, the rugged UV-1650PC, or the UV-1700 - designed to meet your compliance needs. Other models include the single monochromator UV-2401PC, the double-blazed, double monochromator UV-2501PC, and the UV-3101PC, which combines research-grade optical performance in the UV-VIS-NIR with the ease and familiarity of the Windows platform. Visit our Web site for more information.<br>
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Shimadzu Scientific Instruments<br>
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800-477-1227<br>
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<td bgcolor="#990000"><a name="f1"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Shimadzu Biotech and ISB join forces against disease</i></b></FONT></center></td>
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<p>
<strong>Shimadzu Biotech,</strong> a business unit of <strong>Shimadzu Corp.,</strong> will collaborate with the Institute for Systems Biology (ISB), a nonprofit institute committed to identifying strategies for predicting and preventing diseases such as cancer, arthritis, and AIDS. The ISB intends to use the AXIMA-QIT<sup><small>TM</small></sup> MALDI-TOF for its groundbreaking proteomic studies of complex biological samples. The AXIMA-QIT combines a MALDI source, quadrupole ion trap, and time-of-flight mass analyzer to provide true MS-MS and MSn data acquisition with the sensitivity required for current proteomic strategies.
</p>
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<td bgcolor="#990000" colspan=2></A><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Gradipore </i></b></FONT></center></td>
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<td width="100%" valign=top colspan=2><center>
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<td bgcolor="#990000"><a name="f2"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>ProMetic BioSciences helps to purify plasma for the Red Cross</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top align=justify>
<p>
<strong>ProMetic Life Sciences Inc.</strong> announced that its wholly owned U.K. subsidiary, <strong>ProMetic BioSciences Ltd.</strong> and <strong>Hemosol Inc.</strong> signed an important strategic agreement to implement the ProMetic/American Red Cross plasma protein purification process for North America. Through this agreement with Hemosol, ProMetic is now well advanced in its plan to have the first facility of this type based in Canada. Plasma protein fractionation is the largest global therapeutic protein industry. Therapeutic products derived from plasma are used to treat more than one million patients each year.
</p>
</td>
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
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<tr>
<td bgcolor="#990000" colspan=2><a name="f3"></a>
<center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>A Mass Spectrometry Detector Array That Provides Truly Simultaneous Detection</i></b></FONT></center>
</td>
</tr>
<tr>
<td valign=top>
<p>By James H. Barnes IV, Gary M. Hieftje, M. Bonner Denton,
Roger Sperline, David W. Koppenaal, and Charles Barinaga<br><br>
Over the nearly century-long existence of mass spectrometry,
the technique has evolved from a research-laboratory
novelty to a well-characterized, widely
employed method of analysis. With currently available
technology, it is possible to dissect a sample and determine
its composition, both qualitatively and quantitatively,
in bulk and at trace levels, with a great deal of
sensitivity and precision. However, the majority of
recent advances in MS technology have focused on
improving sample introduction methods and mass analyzer
performance, with relatively little attention paid to
ion detection.<br><br>
Unfortunately, available mass spectrometers still have
many shortcomings. These instruments have an inherently
low duty cycle, resulting in the need for larger
sample sizes and longer analysis times. In part, this limited
duty cycle results from the fact that the most common
instruments, based on quadrupole mass spectrometers
(QMS) or sector-field instruments (SFMS), are
capable of monitoring only a single <em>m/z</em> value at a time.
During this measurement, all other analyte signals are
ignored and discarded. Certain MS geometries, such as
time-of-flight (TOF) and ion-trap (IT) MS instruments,
can overcome this limitation to some extent.<br><br>
<A href="http://pull.xmr3.com/p/9873-04F3/69134377/pull5.html">Click Here</A> to read more.
</p>
</td>
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<tr>
<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>Certified Ergonomic Transferpette<sup><small>®</small></sup> electronic Pipette
from BrandTech Scientific
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<TR>
<td width="100%" valign=top colspan=2><center>
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<td valign=top align=justify><p>
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<td bgcolor="#990000" colspan=2><a name="f4"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>SurroMed acquires Bruker Daltonics Inc. mass spectrometers </i></b></FONT></center></td>
</tr>
<tr>
<td valign=top>
</td>
<td valign=top align=justify>
<p>
<strong>Bruker Daltonics Inc.,</strong> an operating company of <strong>Bruker Biosciences Corp.,</strong> and <strong>SurroMed, Inc.</strong> announced the strategic partnership that includes SurroMed's acquisition of Bruker Daltonics' microTOF<sup><small>TM</small></sup> ESI-TOF mass spectrometers for use in SurroMed's Biomarker Discovery Laboratory, as well as collaboration on development of advanced software and sample fractionation products. In conjunction with SurroMed's proprietary MassView<sup><small>TM</small></sup> software, the instruments provide high resolution and mass accuracy that will allow the increase of the number of proteins, peptides, and metabolites identified and quantified from samples.
</p>
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i> Sonics & Materials FASTER ULTRASONIC PROCESSING </i></b></FONT></center></td>
</tr>
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<td width="100%" valign=top colspan=2><center>
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</td>
<td valign=top align=justify>
<p> FASTER ULTRASONIC PROCESSING is made possible using our new multi-element probes. Designed to process 96 samples simultaneously. These probes meet the ever-increasing demand to prepare samples, disrupt cells, disaggregate, homogenize, and more. <br><br>
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</p>
</td>
</tr>
</table>
<table width="100%" bgcolor="#ffffff" cellpadding=3 cellspacing=3>
<tr>
<td bgcolor="#990000"><a name="f5"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Rediscovering Polarized Light
Microscopy
</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top align=justify><p>
by Robert Weaver<br><br>
A microscope able to provide
simultaneous physical, chemical,
and crystallographic data on particles
down to 500 nm would surely
be hailed as an incredible instrument.
This microscope would likely
find itself rapidly integrated into a
variety of materials analysis procedures.
One may be surprised to
learn that a microscope with these
capabilities has existed for more
than 170 years. The polarized light
microscope (PLM) has demonstrated
its value as an indispensable
analytical instrument with continuous
usage and the development of
new applications since its earliest
reported use circa 1834.<sup>1</sup> However,
although the modern PLM is more
useful than ever, there has been a
general decrease in the awareness of
its operation and capabilities in
materials analysis. Several factors
have contributed to this decrease.
<br> <br>
<A href="http://pull.xmr3.com/p/9873-04F3/69134384/pull7.html">Click Here</A> to read more.
</p>
</td>
</tr>
</table>
<table width="100%" bgcolor="#ffffff" cellpadding=3 cellspacing=3>
<tr>
<td bgcolor="#990000"><a name="f6"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>The Swiss approve Erbitux<sup><small>TM</small></sup> for cancer treatment</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top align=justify>
<p>
<strong>Merck KGaA</strong> announced that the Swiss Agency for Therapeutic Products (Swissmedic) has approved the use of Erbitux<sup><small>TM</small></sup> (cetuximab) for the treatment of patients with colorectal cancer who no longer respond to standard chemotherapy treatment with irinotecan. This is the first approval of Erbitux anywhere. The Swiss authorization allows doctors to administer Erbitux in combination with irinotecan. Swissmedic belives that the risk/benefit ratio for the combination therapy is favorable.</p>
</td>
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i> LECO's New TruSpec<sup><small>®</small></sup> Series </i></b></FONT></center></td>
</tr>
<TR>
<td width="100%" valign=top colspan=2><center>
<I>Advertisement</I></center>
</td>
</TR>
<tr>
<td valign=top align=justify>
<p> The TruSpec<sup><small>®</small></sup> Series of Elemental Determinators from LECO Corporation conducts modular N, CN, CHN determination and macro-constituent analysis in under four minutes on up to
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</p>
</td>
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</td>
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<tr>
<td bgcolor="#990000"><a name="f8"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Charles River Proteomic Services (CRPS) and CEM Corp. present a robust platform to enhance the identification of proteins</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top align=justify>
<p>
<strong>CRPS</strong> and <strong>CEM Corp.</strong> developed a robust platform to enhance the identification of proteins by enzymatic digestion and peptide mass fingerprinting based on CEM's Focused<sup><small>TM</small></sup> microwave platform technology. The use of fully controllable, programmable, and focused microwave energy provides a means to greatly accelerate enzymatic digestions while maintaining enzyme integrity, limiting the introduction of unwanted reaction artifacts and reducing the number of missed cleavages. The methodology has proven effective for digestions performed in gel plugs, as well as in free solutions, providing results in a fraction of the time.
</p>
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Top Image: Dorsal root ganglion neurons of an embryonic rat. Taken by Dr. Heiti Paves, Laboratory of Molecular Genetics, Tallinn, Estonia. Third prize in the 2003 Nikon International Small World Competition.</small>
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