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<td bgcolor="#ffffff" width="50%"><p><STRONG><EM>Laboratory Instrumentation
News</EM></STRONG> is published by International Scientific
Communications, Inc., the publisher of <STRONG><EM>American
Laboratory</EM></STRONG> and <STRONG><EM>American Biotechnology
Laboratory,</EM></STRONG> your up-to-date source for industry news,
information on new products, and links to authoritative technical articles
and application notes. You are receiving this e-mail newsletter free of
charge as a subscriber to one of our publications. We hope you will find
the information provided in this e-newsletter interesting and informative.
If you prefer not to receive <STRONG><EM>Laboratory Instrumentation
News,</EM></STRONG>
simply follow the unsubscribe instructions below.</p>
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<font color=#990000
> <b>In This November 2003 Issue</b></font>
<UL>
<li type=disc><A style="COLOR: #990000" href="#f1">Industry News: InnaPhase Corp., Acquires a Beckman Coulter Division</A>
<li type=disc><A style="COLOR: #990000" href="#f2">Industry News: Investment in Detroit-Based Human Tissue Research Bank</A>
<li type=disc><A style="COLOR: #990000" href="#f3">Flipbook </A>
<li type=disc><A style="COLOR: #990000" href="#f4">Article: Statistics in Analytical Chemistry</A>
<li type=disc><A style="COLOR: #990000" href="#f5">Industry News: Pyrosequencing AB's New Management Team</A>
<li type=disc><A style="COLOR: #990000" href="#f6">Industry News: GV Instruments by Brian Howard</A>
<li type=disc><A style="COLOR: #990000" href="#f7">Industry News: Nikon 2003 Small World Photomicrography Competition</A>
<li type=disc><A style="COLOR: #990000" href="#f8">Article: Progress and Prospects of Protein
Therapeutics</A>
<li type=disc><A style="COLOR: #990000" href="#f9">Industry News: Clinical Proteomics Survey</A>
<li type=disc><A style="COLOR: #990000" href="#f10">Article: Glycosylation: Art and Science</A></li></UL>
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
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<td bgcolor="#990000"><a name="f1"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>InnaPhase Corp. Acquires a Beckman Coulter Division</i></b></FONT></center></td>
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<td valign=top align=justify><p> <strong>InnaPhase Corp.,</strong> a privately owned software
company and provider of LIMS solutions for the life sciences market, will
acquire <STRONG>Beckman Coulter's Laboratory Automation
Operations,</STRONG> which has been a leading provider of LIMS used for
the collection and management of data in pharmaceutical research and
development processes. The acquisition expands InnaPhase's portfolio of
pharmaceutical solutions and catapults the company to the position of
largest LIMS vendor in the world. InnaPhase Corp. markets the Pharma LIMS™
and Pharma AIMS™ suites, providing 18 of the world's top 20 pharmaceutical
organizations with its products and services.</p>
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<td bgcolor="#990000" colspan=2></A><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Aqueous Extractions</i></b></FONT></center></td>
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<td bgcolor="#990000"><a name="f2"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Investment in Detroit-Based Human Tissue Research Bank</i></b></FONT></center></td>
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<td valign=top align=justify><p> With money it
received from a settlement with the tobacco industry, the State of
Michigan has invested in a Detroit-based human tissue research bank. The
cash settlement has been allocated to a joint research program to be
carried out by Wayne State University and <STRONG>Asterand</STRONG> . Genomics technology will be used to speed the discovery of new treatments and diagnostics for cancers and other major human diseases. This will include genotyping of blood, mouthwash, and tissue samples. For more information, <A href="http://pull.xmr3.com/p/9102-2DD5/48366268/pull22.html">Click Here.</A></p>
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<center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i> ISC Inc. Displays its September Postcard Deck </i></b></FONT></center>
</td>
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<td valign=top><img src="http://www.isc-newsletter.com/newsletter/nov03/lin/scrnshot2.jpg" width=150 border=0>
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<p> The ISC staff is pleased to offer the September issue of the <b>ISC Laboratory Product Postcard Deck</b> in a new and improved digital edition format. More than a simple replica of the print postcard deck, the e-edition has interactive pages and provides enhanced content. Better still, it is easy to navigate and fun to use. <A href="http://pull.xmr3.com/p/9102-2DD5/48366270/pull3.html">Click Here</A> for more information. </p>
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Shimadzu’s GCMS-QP2010 Sets a New Industry Standard for Speed and Sensitivity</i></b></FONT></center></td>
</tr>
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<td valign=top align=justify><p> The QP-2010 has a scan sensitivity over 200/1 for 1 pg of OFN and provides acquisition speeds to 50 scans/second. Twenty temperature ramps and patented Constant Linear Velocity ensure optimum separation. The capability to use virtually any type of column, in EI, CI or NCI mode with a variety of inert reproducible injection systems, makes the QP2010 the most versatile GC/MS system available.
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i> Statistics in Analytical Chemistry
</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top>
</td>
<td valign=top align=justify><a name="f4"></a>
<p> This series of
articles by David Coleman and Lynn Vanatta covers a selection of topics in basic statistics for laboratory scientists. Everyone will benefit from reviewing these contributions, whether you are an experienced professional, laboratory technician, or student.
<br><br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366412/pull5.html">Part 1: A new American Laboratory column.</A><br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366415/pull6.html">Part 2: Measurement and the real-number line</A> <br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366418/pull7.html">Part 3: Calibration—Introduction and ordinary least squares</A> <br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366420/pull8.html">Part 4: Calibration: Uncertainty intervals </A><br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366486/pull9.html">Part 5: Calibration: Calibration design </A><br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366150/pull10.html">Part 6: Calibration design </A><br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366152/pull11.html">Part 7: A Review</A><br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366156/pull12.html">Part 8: Calibration Diagnostics</A>
</p>
</td>
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<td bgcolor="#990000"><a name="f5"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Pyrosequencing AB's New Management Team</i></b></FONT></center></td>
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<tr>
<td valign=top align=justify><p> <strong>Pyrosequencing AB</strong> announced the appointment of a new management team in connection with its completion of a merger with <strong>Personal Chemistry</strong> . Pyrosequencing AB develops, manufactures, and markets complete solutions for rapid, applied genetic analysis based on its proprietary Pyrosequencing™ technology, a widely applicable DNA sequencing technique.</p>
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>PRECISION DISPENSERS & METERING PUMPS</i></b></FONT></center></td>
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<td valign=top><IMG src="http://www.isc-newsletter.com/newsletter/nov03/lin/fmi200.jpg" border=0>
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<td valign=top align=justify><p> <strong>Fluid Metering, Inc.</strong> has released their <B><I>NEW</I></B> 2003 30-page catalog covering Dispensers and Metering Pumps for Laboratory, Industrial, and OEM applications. Featured is their <b><i>NEW</i> IDS2000 Industrial Dispenser</b> designed for integration into 24/7 production applications. FMI features unique piston-type positive displacement units with no valves, low-dead volume, 1% accuracy and a ceramic/fluorocarbon fluid path. Flows from 2.5 µL/dispense to flows of 4,600 ML/min with pressures to 100 psig. Fluid Metering is certified as compliant with ISO <b>9001</b> quality standards. The catalog details operating principles, pump capacities, motor characteristics, materials of construction, prices and ordering information.
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<td bgcolor="#990000"><a name="f6"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>GV Instruments Review by Brian Howard</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top align=justify>
<p> Earlier this year a new mass spectrometer
company named <strong>GV Instruments</strong> entered the laboratory
marketplace. GV began trading in
April 2003 in a new manufacturing
site located in Wythenshawe, just
outside Manchester, U.K. The company’s
logo carries the tag line:
“Reflecting 25 years of mass spectrometry,”
a surprising assertion for a
new company, but the roots of GV
go back many years. Manchester has
always been a key center for mass
spectrometry. I met with Dr. Tony
Williams, Managing Director, who
explained that GV Instruments has
its origin in the VG Isotopes business,
which was split off from the
organic mass spectrometry business
of VG Instruments in the late 1970s.<br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366209/pull14.html">Click Here</A> to read more.</p>
<hr color="#990000" width="75%"> </hr>
<p> GV
Instruments (GVI) secured two IsoProbe-T™ TIMS orders from high-profile geological laboratories in China. The instruments will be used for isotope geochemistry, cosmochemistry, and geochronology. Both systems are configured with the latest in detection capability. This deal builds on the relationship between GVI personnel and renowned Chinese scientists that has been established over the past 25 years.</p>
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<td bgcolor="#990000"><a name="f7"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Nikon 2003 Small World Photomicrography Competition</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top align=justify><p> <strong>Nikon Instruments, Inc.</strong> has announced the winners of the Nikon 2003 Small World Photomicrography Competition: Dr. Torsten Wittman (The Scripps Research Institute)–first prize, Dr. Greg Rouse (South Australia Museum)–second prize, and Dr. Heiti Paves (Laboratory of Molecular Genetics in Estonia)–third prize. The contest was founded in 1975 to recognize excellence in photography through the microscope. The winning images are made accessible to the public through the Nikon Small World calendar, a national museum tour, and an electronic gallery featured on Nikon Instrument's Web site. <br><A href="http://pull.xmr3.com/p/9102-2DD5/48366211/pull15.html">Click Here</A> for more information. </p>
</td>
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<td bgcolor="#990000"><a name="f8"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Progress and Prospects of Protein
Therapeutics by Rathin Das</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top align=justify><p> During the past two decades, the medical biotechnology
industry has successfully brought more than
160 drugs and vaccines to the marketplace. Additionally,
according to the Pharmaceutical Research
and Manufacturing Association (PHRMA), there
are over 371 new products currently in clinical trials
targeting more than 200 diseases. These include
AIDS, Alzheimer’s disease, arthritis, cancer, diabetes,
heart disease, and multiple sclerosis. A large
proportion of these drugs are protein-based therapeutics,
which are primarily injectables and are
generally more expensive than small-molecule
drugs. Indeed, a year’s supply of some of the protein
drugs could be in the range of $10,000 or more. <br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366213/pull16.html">Click Here</A> to read more.</p>
</td>
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Laboratory Balances from Sartorius</i></b></FONT></center></td>
</tr>
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<td width="100%" align=justify><h5>CP Series from Sartorius Excellent performance. Exceptional value.</h5><p> The CP Series of
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offers a totally new design and several unique features, including a large, triangular-shaped weigh pan; a new, modular design draft shield; and an exceptionally bright backlit display with extra large digits. There are 25 models in the CP Series including analyticals, top loaders, and 2 newly redesigned microbalances. The balances offer readabilities from 0.001 mg to 1 g and weighing capacities from 2 g to 34 kg. Advanced monolithic load cell technology offers faster response times and reduced susceptibility to temperature drifts. All models have been affordably priced.
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<P></P>
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<td bgcolor="#990000"><a name="f9"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Clinical Proteomics Survey</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top align=justify><p> In a detailed survey entitled, "Clinical Proteomics: A First-Glance Market Report," the market research firm, <strong>BioInformatics, LLC,</strong> reports that clinical proteomics stands to revolutionize the huge clinical testing market, and that cancer and infectious disease are two conditions believed to be the best candidates for prognostic or diagnostic assays based on protein profiling. The report provides the thoughts of more than 300 proteomics researchers on the disease applications, assay formats, and technical standards for protein profiling assays that will be used for disease prognosis or diagnosis in a clinical setting. <A href="http://pull.xmr3.com/p/9102-2DD5/48366217/pull18.html">Click Here</A> for more information.</p>
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<td bgcolor="#990000" colspan=2><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>The Lee LabKit</i></b></FONT></center></td>
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<td valign=top><IMG src="http://www.isc-newsletter.com/newsletter/nov03/lin/leecomapny.jpg"
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</td>
<td valign=top align=justify><p> Ideal for liquid handling applications, the new LabKit<SUP><small>TM</small></SUP> is an integrated fluidic module, incorporating The Lee Company's high resolution LPV variable volume pumps (250 or 750 µL) and miniature precision valves (2 or 3-way models). <A href="http://pull.xmr3.com/p/9102-2DD5/48366265/pull21.html">Click Here</A> for more information on our complete line of miniature fluid control components for medical and scientific instrumentation.
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<tr>
<td bgcolor="#990000"><a name="f10"></a><center><FONT face=Arial,Helvetica,sans-serif color=#ffffff size=3><b>
<i>Glycosylation: Art and Science</i></b></FONT></center></td>
</tr>
<tr>
<td valign=top align=justify><p> Of all the post-translational modifications
that occur in proteins, glycosylation
is the most extensive and variable.
The study of glycosylation, termed glycobiology,
has recently reinvented itself
as the discipline of glycomics.
Analytical and synthetic protocols for
the study of oligosaccharides had not
developed at the same pace as technology
for DNA and protein sequencing,
but now off-the-shelf technologies are
becoming available that will allow nonspecialist
laboratories to determine the
structural and functional role of
oligosaccharides in glycoproteins.<br>
<A href="http://pull.xmr3.com/p/9102-2DD5/48366263/pull20.html">Click Here</A> to read more.</p>
</td>
</tr>
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