[Biopython] quantile normalization method

Vincent Davis vincent at vincentdavis.net
Sat Mar 20 03:56:46 UTC 2010


Is there a quantile normalization method in biopython, I search but did not
find. If not it looks straight forward would it be of any interest to the
community for me to contribute a method


1. given n arrays of length p, form X of dimension
p × n where each array is a column;
2. sort each column of X to give X sort ;
3. take the means across rows of X sort and assign this
mean to each element in the row to get X sort ;
4. get X normalized by rearranging each column of
X sort to have the same ordering as original X

From
A comparison of normalization methods for high
density oligonucleotide array data based on
variance and bias
B. M. Bolstad 1,∗, R. A. Irizarry 2, M. Astrand 3 and T. P. Speed 4, 5
˚


  *Vincent Davis
720-301-3003 *
vincent at vincentdavis.net
 my blog <http://vincentdavis.net> |
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