[BioPython] Translation of ambiguous codons like NNN and TAN

Peter biopython at maubp.freeserve.co.uk
Tue Jul 22 08:51:26 UTC 2008


On Mon, Jul 21, 2008 at 10:04 PM, Peter <biopython at maubp.freeserve.co.uk> wrote:
>> The relevant document here is the IUPAC 'Nomenclature for Incompletely
>> Specified Bases in Nucleic Acid Sequences'
>>  (http://www.chem.qmul.ac.uk/iubmb/misc/naseq.html).
>>
>> Table 4 ...
>
> I'd seen that table, but hadn't interpreted it in quite the same way
> as you seem to have.  ...
> So on the basis of Table 4, there is no reason to infer that IUPAC
> explicitly suggest NNN should be translated as X.

Re-reading that, I can be pedantic sometime, can't I?

Putting our differences of opinion about exactly what the IUPAC Table
4 is intended to convey, do you agree that Biopython's
Bio.Seq.translate() function should turn NNN and TAN into X?

Thanks

Peter



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