From biopython at maubp.freeserve.co.uk Mon Apr 6 08:15:42 2009 From: biopython at maubp.freeserve.co.uk (Peter) Date: Mon, 6 Apr 2009 13:15:42 +0100 Subject: [Biopython-announce] Fwd: CFP: NETTAB 2009 on Collaborative Bioinformatics Research and Development (open source, social networks, wikis, ...) In-Reply-To: <200904060841.n368fbGi005771@clus2.istge.it> References: <200904060841.n368fbGi005771@clus2.istge.it> Message-ID: <320fb6e00904060515s3990aedaj7f1bfe75c0c55d19@mail.gmail.com> I hope this will be of interest to some of our subscribers, Peter ---------- Forwarded message ---------- From: Paolo Romano Date: Apr 6, 2009 9:41 AM Subject: CFP: NETTAB 2009 on Collaborative Bioinformatics Research and Development (open source, social networks, wikis, ...) To: biopython-owner at lists.open-bio.org Dear list owner, I think the following announce could be of interest for biopython list members. So, please, could you forward it to the list? Many thanks in advance. Paolo =========================== Apologies if you receive more copies. =========================== Announce and Preliminary Call for Papers NETTAB 2009 Workshop on "Technologies, Tools and Applications for Collaborative and Social Bioinformatics Research and Development" with a Special Session on: "Methods and Tools for RNA Structure and Functional Analysis" June 10-13, 2009 Department of Computer Science, University of Catania, Italy http://www.nettab.org/2009/ Submissions deadlines: - April 28, 2009: Oral communication submission - May 15, 2009: Posters submission Submissions must be short papers of around 3 pages or 12.000 characters long. Special Issues in peer-review journals on workshop's topics planned: post-workshop ad hoc Call for papers will be issued. RATIONALE Advent of Wide Area Networks (WAN) allowed the availability of distributed information and prompted the need for searching and retrieving this data (Network Information Retrieval tools, NIR), as well the development of unprecedented communications between users (Computer Mediated Communication tools, CMC). Initially, CMC was asynchronous and based on electronic mail and newsgroups. From email systems, mailing lists and newsletter were soon derived, while newsgroups generated, shortly after, electronic fora. Synchronous communication were introduced through the advent of chat services. On this line, current multimedia teleconference systems were then set up. Virtual reality was first introduced for educational purposes by means of MUD (Multi-users Domain) systems, and especially by means of MOO (MUD Object-oriented). This line produced current virtual reality environment, like the emerging Second Life system. Life Sciences researchers largely took profit from CMC tools. The bionet newsgroups hierarchy remains one of the most famous and useful CMC system supporting life science research. Many mailing lists that were born in that context are still used. The development of open source software was largely made possible by the possibility of exchanging, in an effective way, knowledge, practices and skills among researchers. Web sites of communities of scientists were set up and often constituted the base for a real collaborative development and research. The most recent developments of collaborative development tools are impressive. Researchers can now collaboratively develop software (open source systems), discuss and compare development strategies (social networks), write documents (google docs, wiki systems), build knowledge bases. So, it may now be the time for presenting current technologies, tools and applications for collaborative work and for discussing perspectives of their utilization in support of Bioinformatics. For these reasons, NETTAB 2009 will be devoted to "Technologies, Tools and Applications for Collaborative and Social Bioinformatics Research and Development". Moreover, there will be a special session on "Methods and Tools for RNA Structure and Functional Analysis". The transcription of almost all genomes generates a great number of coding and non-coding RNAs (ncRNAs). Although RNA is central to the synthesis of proteins, it is not only a messenger of genetic information: many cellular functions depend on ncRNAs, which exert their functions by their sequence and structure. In particular, small silencing RNAs (miRNAs, siRNAs and piRNAs) play a crucial role in many physiological processes and their aberrant expression is a common feature of human diseases including cancer. Models and tools able to increase our understanding of RNAs functions and their involvement in diseases may lead to the design of new RNA-based therapeutics. The RNA community is also taking advantage of collaborative research tools such as Wikis and other virtual environments. The RNA WikiProject contains now over 600 articles describing families of noncoding RNAs based on the Rfam database, and invite the community to update, edit, and correct those articles. Therefore, the NETTAB 2009 special session will focus on collaborative research project, computational methods and tools for the analysis of RNA structures and functions, with a special emphasis on ncRNAs. KEYNOTE SPEAKER # Alex Bateman Wellcome Trust Sanger Institute Hinxton, Cambridge, UK # Tim Clark Director of Informatics, MassGeneral Institute for Neurodegenerative Disease Neurology Research Department, Massachusetts General Hospital, Boston, USA # Duncan Hull School of Chemistry, University of Manchester, Manchester, UK # Michael Levitt Stanford University, USA # Debora Marks Systems Biology Department, Harvard Medical School Boston, USA TOPICS - Collaborative Web sites (bioinformatics.org, biojava, bioperl, ?) - Communities of Practices (CoPs) Scientific practices in scientific communities Automatic detection / gathering / modelling of scientific practices Implementations of CoPs - Social networking (myExperiment, Annotea, myScience) Social Bookmarking Semantic Document Markup Relationships mining from literature - Open Source development Sharing of data models, libraries, interfaces - Social software for collaborative documentation development Wikis, blogs, google docs Knowledge Wikis Social-software-mediated collaborative scientific research Social-software-mediated collaborative tools' development Knowledge base collaborative development Ontologies collaborative development - Education and training tools E-learning Virtual environments Methods and Tools for RNA Structure and Functional Analysis - RNA structure prediction - Collaborative studies of RNAs - ncRNAs functional analysis and classification - miRNAs and networks - Genome-wide functional studies - Identification of ncRNAs - Databases of ncRNAs and miRNA targets - miRNA targets prediction - Synthetic miRNA and siRNA design - Gene expression analysis - Analysis of viral RNAs - RNAi therapeutics - Identification of ncRNAs biomarkers - RNA-protein interaction prediction DEADLINES Submissions for both oral communications and posters must be short papers of around THREE A4 pages or 12.000 characters long. - April 28, 2009: Oral communication submission Acceptation communication: May 12, 2009 - May 15, 2009: Posters submission - May 17, 2009: Early registration - June 10-13, 2009: Tutorials and Workshop Calls for SPECIAL ISSUES We plan to launch Calls for Special Issues on the themes of the workshop in peer-review journals with associated Impact factor around July for submission in September 2009. Best regards. Paolo Romano on behalf of NETTAB 2009 Chairs Paolo Romano (paolo.romano at istge.it) Bioinformatics National Cancer Research Institute (IST) Largo Rosanna Benzi, 10, I-16132, Genova, Italy Tel: +39-010-5737-288 Fax: +39-010-5737-295 AIUTACI AD AIUTARE: Il tuo 5 per MILLE a sostegno della nostra RICERCA. Come fare: Nella prossima dichiarazione dei redditi metti la firma nell'apposito riquadro del 5 per mille, scrivendo anche il codice fiscale dell'Istituto Nazionale per la Ricerca sul Cancro di Genova : c.f. 80 100 850 108 Istituto Nazionale per la Ricerca sul Cancro L.go R. Benzi, 10 -16132 Genova http://www.istge.it NETTAB '09 - Ninth International Workshop on Network Tools and Applications in Biology 10-13 June 2009, Catania, Italy http://www.nettab.org/2009/ (soon available) Paolo Romano (paolo.romano at istge.it) Bioinformatics National Cancer Research Institute (IST) AIUTACI AD AIUTARE: Il tuo 5 per MILLE a sostegno della nostra RICERCA. Come fare: Nella prossima dichiarazione dei redditi metti la firma nell'apposito riquadro del 5 per mille, scrivendo anche il codice fiscale dell'Istituto Nazionale per la Ricerca sul Cancro di Genova : c.f. 80 100 850 108 Istituto Nazionale per la Ricerca sul Cancro L.go R. Benzi, 10 -16132 Genova http://www.istge.it From biopython at maubp.freeserve.co.uk Mon Apr 20 15:02:18 2009 From: biopython at maubp.freeserve.co.uk (Peter) Date: Mon, 20 Apr 2009 20:02:18 +0100 Subject: [Biopython-announce] Biopython 1.50 released Message-ID: <320fb6e00904201202j4bb9666es18c89136ce973a48@mail.gmail.com> Dear all, We are pleased to announce Biopython release 1.50, featuring some significant additions since Biopython 1.49 was released late last year. GenomeDiagram by Leighton Pritchard has been integrated into Biopython as the Bio.Graphics.GenomeDiagram module. A new module Bio.Motif has been added, which is intended to replace the existing Bio.AlignAce and Bio.MEME modules. Also have a look at Bio.SwissProt and Bio.ExPASy and their revised parsers. As noted in a previous news posting, Bio.SeqIO can now read and write FASTQ and QUAL files used in second generation sequencing work. In connection with this, our SeqRecord object has a new dictionary attribute, letter_annotations, for per-letter-annotation information like sequence quality scores or secondary structure predictions. Also, the SeqRecord object can now be sliced to give a new SeqRecord covering just part of the sequence. Biopython 1.50 supports Python 2.3, 2.4, 2.5 and 2.6. However, this is expected to be the final version to support Python 2.3 (see this previous announcement). Also, Biopython 1.50 should be the last release to include our old deprecated parsing infrastructure (Martel and Bio.Mindy). We?ve also updated the Biopython Tutorial and Cookbook (also available in PDF), and not just by adding our logo to the cover ;) http://biopython.org/DIST/docs/tutorial/Tutorial.html http://biopython.org/DIST/docs/tutorial/Tutorial.pdf Thank you to everyone who tested the Biopython 1.50 beta release, and to all our contributors. Source distributions and Windows installers are available from the downloads page on the Biopython website: http://biopython.org/wiki/Download -Peter, on behalf of the Biopython developers P.S. This news post is online at http://news.open-bio.org/news/2009/04/biopython-release-150/ You may wish to subscribe to our news feed. For RSS links etc, see: http://biopython.org/wiki/News From biopython at maubp.freeserve.co.uk Wed Apr 29 11:15:25 2009 From: biopython at maubp.freeserve.co.uk (Peter) Date: Wed, 29 Apr 2009 16:15:25 +0100 Subject: [Biopython-announce] Fwd: NETTAB 2009: Deadline postponed to May 4, 2009, for Oral communications In-Reply-To: <200904291438.n3TEcvPY041258@ibm43p.biotech.ist.unige.it> References: <200904291438.n3TEcvPY041258@ibm43p.biotech.ist.unige.it> Message-ID: <320fb6e00904290815v51728e4du8a1264ecc0a86263@mail.gmail.com> FYI ---------- Forwarded message ---------- From: Paolo Romano Date: Wed, Apr 29, 2009 at 3:24 PM Subject: NETTAB 2009: Deadline postponed to May 4, 2009, for Oral communications To: biopython-owner at lists.open-bio.org Would you please forward this message to the list? Many thanks. Paolo ==== Due to many requests for a new deadline for submission of contributions for oral communications, the related deadline has been postponed to: Monday May 4, 2009, at 12.00 (noon), EST (GMT+1). ===== Last Call for Oral communications NETTAB 2009 Workshop on "Technologies, Tools and Applications for Collaborative and Social Bioinformatics Research and Development" with a Special Session on: "Methods and Tools for RNA Structure and Functional Analysis" June 10-13, 2009 Department of Computer Science, University of Catania, Italy http://www.nettab.org/2009/ Deadline approaching: May 4, 2009: Oral communication submission Contributions must be short papers of around THREE A4 pages or 12.000 characters long. Submit through the EasyChair system at: http://www.easychair.org/conferences/?conf=nettab2009 . See web site for details. Invited Speakers: Alex Bateman, Doron Betel, Tim Clark, Duncan Hull, Gabriel Valiente, Debora Marks, Gabriel Valiente Topics (see the web site for an extended list) - Collaborative Web sites, - Social networking - Open Source development - Social software for collaborative documentation development - Wikis, blogs, google docs - Ontologies collaborative development - Methods and Tools for RNA Structure and Functional Analysis Deadlines - May 4, 2009: Oral communication submission - May 15, 2009: Posters submission - May 17, 2009: Early registration Calls for SPECIAL ISSUES We plan to launch Calls for Special Issues on the themes of the workshop in peer-review journals with associated Impact factor around July for submission in September 2009. Best regards. Paolo Romano on behalf of NETTAB 2009 Chairs NETTAB '09 - Ninth International Workshop on Network Tools and Applications in Biology 10-13 June 2009, Catania, Italy http://www.nettab.org/2009/ Paolo Romano (paolo.romano at istge.it) Bioinformatics National Cancer Research Institute (IST) From biopython at maubp.freeserve.co.uk Mon Apr 6 12:15:42 2009 From: biopython at maubp.freeserve.co.uk (Peter) Date: Mon, 6 Apr 2009 13:15:42 +0100 Subject: [Biopython-announce] Fwd: CFP: NETTAB 2009 on Collaborative Bioinformatics Research and Development (open source, social networks, wikis, ...) In-Reply-To: <200904060841.n368fbGi005771@clus2.istge.it> References: <200904060841.n368fbGi005771@clus2.istge.it> Message-ID: <320fb6e00904060515s3990aedaj7f1bfe75c0c55d19@mail.gmail.com> I hope this will be of interest to some of our subscribers, Peter ---------- Forwarded message ---------- From: Paolo Romano Date: Apr 6, 2009 9:41 AM Subject: CFP: NETTAB 2009 on Collaborative Bioinformatics Research and Development (open source, social networks, wikis, ...) To: biopython-owner at lists.open-bio.org Dear list owner, I think the following announce could be of interest for biopython list members. So, please, could you forward it to the list? Many thanks in advance. Paolo =========================== Apologies if you receive more copies. =========================== Announce and Preliminary Call for Papers NETTAB 2009 Workshop on "Technologies, Tools and Applications for Collaborative and Social Bioinformatics Research and Development" with a Special Session on: "Methods and Tools for RNA Structure and Functional Analysis" June 10-13, 2009 Department of Computer Science, University of Catania, Italy http://www.nettab.org/2009/ Submissions deadlines: - April 28, 2009: Oral communication submission - May 15, 2009: Posters submission Submissions must be short papers of around 3 pages or 12.000 characters long. Special Issues in peer-review journals on workshop's topics planned: post-workshop ad hoc Call for papers will be issued. RATIONALE Advent of Wide Area Networks (WAN) allowed the availability of distributed information and prompted the need for searching and retrieving this data (Network Information Retrieval tools, NIR), as well the development of unprecedented communications between users (Computer Mediated Communication tools, CMC). Initially, CMC was asynchronous and based on electronic mail and newsgroups. From email systems, mailing lists and newsletter were soon derived, while newsgroups generated, shortly after, electronic fora. Synchronous communication were introduced through the advent of chat services. On this line, current multimedia teleconference systems were then set up. Virtual reality was first introduced for educational purposes by means of MUD (Multi-users Domain) systems, and especially by means of MOO (MUD Object-oriented). This line produced current virtual reality environment, like the emerging Second Life system. Life Sciences researchers largely took profit from CMC tools. The bionet newsgroups hierarchy remains one of the most famous and useful CMC system supporting life science research. Many mailing lists that were born in that context are still used. The development of open source software was largely made possible by the possibility of exchanging, in an effective way, knowledge, practices and skills among researchers. Web sites of communities of scientists were set up and often constituted the base for a real collaborative development and research. The most recent developments of collaborative development tools are impressive. Researchers can now collaboratively develop software (open source systems), discuss and compare development strategies (social networks), write documents (google docs, wiki systems), build knowledge bases. So, it may now be the time for presenting current technologies, tools and applications for collaborative work and for discussing perspectives of their utilization in support of Bioinformatics. For these reasons, NETTAB 2009 will be devoted to "Technologies, Tools and Applications for Collaborative and Social Bioinformatics Research and Development". Moreover, there will be a special session on "Methods and Tools for RNA Structure and Functional Analysis". The transcription of almost all genomes generates a great number of coding and non-coding RNAs (ncRNAs). Although RNA is central to the synthesis of proteins, it is not only a messenger of genetic information: many cellular functions depend on ncRNAs, which exert their functions by their sequence and structure. In particular, small silencing RNAs (miRNAs, siRNAs and piRNAs) play a crucial role in many physiological processes and their aberrant expression is a common feature of human diseases including cancer. Models and tools able to increase our understanding of RNAs functions and their involvement in diseases may lead to the design of new RNA-based therapeutics. The RNA community is also taking advantage of collaborative research tools such as Wikis and other virtual environments. The RNA WikiProject contains now over 600 articles describing families of noncoding RNAs based on the Rfam database, and invite the community to update, edit, and correct those articles. Therefore, the NETTAB 2009 special session will focus on collaborative research project, computational methods and tools for the analysis of RNA structures and functions, with a special emphasis on ncRNAs. KEYNOTE SPEAKER # Alex Bateman Wellcome Trust Sanger Institute Hinxton, Cambridge, UK # Tim Clark Director of Informatics, MassGeneral Institute for Neurodegenerative Disease Neurology Research Department, Massachusetts General Hospital, Boston, USA # Duncan Hull School of Chemistry, University of Manchester, Manchester, UK # Michael Levitt Stanford University, USA # Debora Marks Systems Biology Department, Harvard Medical School Boston, USA TOPICS - Collaborative Web sites (bioinformatics.org, biojava, bioperl, ?) - Communities of Practices (CoPs) Scientific practices in scientific communities Automatic detection / gathering / modelling of scientific practices Implementations of CoPs - Social networking (myExperiment, Annotea, myScience) Social Bookmarking Semantic Document Markup Relationships mining from literature - Open Source development Sharing of data models, libraries, interfaces - Social software for collaborative documentation development Wikis, blogs, google docs Knowledge Wikis Social-software-mediated collaborative scientific research Social-software-mediated collaborative tools' development Knowledge base collaborative development Ontologies collaborative development - Education and training tools E-learning Virtual environments Methods and Tools for RNA Structure and Functional Analysis - RNA structure prediction - Collaborative studies of RNAs - ncRNAs functional analysis and classification - miRNAs and networks - Genome-wide functional studies - Identification of ncRNAs - Databases of ncRNAs and miRNA targets - miRNA targets prediction - Synthetic miRNA and siRNA design - Gene expression analysis - Analysis of viral RNAs - RNAi therapeutics - Identification of ncRNAs biomarkers - RNA-protein interaction prediction DEADLINES Submissions for both oral communications and posters must be short papers of around THREE A4 pages or 12.000 characters long. - April 28, 2009: Oral communication submission Acceptation communication: May 12, 2009 - May 15, 2009: Posters submission - May 17, 2009: Early registration - June 10-13, 2009: Tutorials and Workshop Calls for SPECIAL ISSUES We plan to launch Calls for Special Issues on the themes of the workshop in peer-review journals with associated Impact factor around July for submission in September 2009. Best regards. Paolo Romano on behalf of NETTAB 2009 Chairs Paolo Romano (paolo.romano at istge.it) Bioinformatics National Cancer Research Institute (IST) Largo Rosanna Benzi, 10, I-16132, Genova, Italy Tel: +39-010-5737-288 Fax: +39-010-5737-295 AIUTACI AD AIUTARE: Il tuo 5 per MILLE a sostegno della nostra RICERCA. Come fare: Nella prossima dichiarazione dei redditi metti la firma nell'apposito riquadro del 5 per mille, scrivendo anche il codice fiscale dell'Istituto Nazionale per la Ricerca sul Cancro di Genova : c.f. 80 100 850 108 Istituto Nazionale per la Ricerca sul Cancro L.go R. Benzi, 10 -16132 Genova http://www.istge.it NETTAB '09 - Ninth International Workshop on Network Tools and Applications in Biology 10-13 June 2009, Catania, Italy http://www.nettab.org/2009/ (soon available) Paolo Romano (paolo.romano at istge.it) Bioinformatics National Cancer Research Institute (IST) AIUTACI AD AIUTARE: Il tuo 5 per MILLE a sostegno della nostra RICERCA. Come fare: Nella prossima dichiarazione dei redditi metti la firma nell'apposito riquadro del 5 per mille, scrivendo anche il codice fiscale dell'Istituto Nazionale per la Ricerca sul Cancro di Genova : c.f. 80 100 850 108 Istituto Nazionale per la Ricerca sul Cancro L.go R. Benzi, 10 -16132 Genova http://www.istge.it From biopython at maubp.freeserve.co.uk Mon Apr 20 19:02:18 2009 From: biopython at maubp.freeserve.co.uk (Peter) Date: Mon, 20 Apr 2009 20:02:18 +0100 Subject: [Biopython-announce] Biopython 1.50 released Message-ID: <320fb6e00904201202j4bb9666es18c89136ce973a48@mail.gmail.com> Dear all, We are pleased to announce Biopython release 1.50, featuring some significant additions since Biopython 1.49 was released late last year. GenomeDiagram by Leighton Pritchard has been integrated into Biopython as the Bio.Graphics.GenomeDiagram module. A new module Bio.Motif has been added, which is intended to replace the existing Bio.AlignAce and Bio.MEME modules. Also have a look at Bio.SwissProt and Bio.ExPASy and their revised parsers. As noted in a previous news posting, Bio.SeqIO can now read and write FASTQ and QUAL files used in second generation sequencing work. In connection with this, our SeqRecord object has a new dictionary attribute, letter_annotations, for per-letter-annotation information like sequence quality scores or secondary structure predictions. Also, the SeqRecord object can now be sliced to give a new SeqRecord covering just part of the sequence. Biopython 1.50 supports Python 2.3, 2.4, 2.5 and 2.6. However, this is expected to be the final version to support Python 2.3 (see this previous announcement). Also, Biopython 1.50 should be the last release to include our old deprecated parsing infrastructure (Martel and Bio.Mindy). We?ve also updated the Biopython Tutorial and Cookbook (also available in PDF), and not just by adding our logo to the cover ;) http://biopython.org/DIST/docs/tutorial/Tutorial.html http://biopython.org/DIST/docs/tutorial/Tutorial.pdf Thank you to everyone who tested the Biopython 1.50 beta release, and to all our contributors. Source distributions and Windows installers are available from the downloads page on the Biopython website: http://biopython.org/wiki/Download -Peter, on behalf of the Biopython developers P.S. This news post is online at http://news.open-bio.org/news/2009/04/biopython-release-150/ You may wish to subscribe to our news feed. For RSS links etc, see: http://biopython.org/wiki/News From biopython at maubp.freeserve.co.uk Wed Apr 29 15:15:25 2009 From: biopython at maubp.freeserve.co.uk (Peter) Date: Wed, 29 Apr 2009 16:15:25 +0100 Subject: [Biopython-announce] Fwd: NETTAB 2009: Deadline postponed to May 4, 2009, for Oral communications In-Reply-To: <200904291438.n3TEcvPY041258@ibm43p.biotech.ist.unige.it> References: <200904291438.n3TEcvPY041258@ibm43p.biotech.ist.unige.it> Message-ID: <320fb6e00904290815v51728e4du8a1264ecc0a86263@mail.gmail.com> FYI ---------- Forwarded message ---------- From: Paolo Romano Date: Wed, Apr 29, 2009 at 3:24 PM Subject: NETTAB 2009: Deadline postponed to May 4, 2009, for Oral communications To: biopython-owner at lists.open-bio.org Would you please forward this message to the list? Many thanks. Paolo ==== Due to many requests for a new deadline for submission of contributions for oral communications, the related deadline has been postponed to: Monday May 4, 2009, at 12.00 (noon), EST (GMT+1). ===== Last Call for Oral communications NETTAB 2009 Workshop on "Technologies, Tools and Applications for Collaborative and Social Bioinformatics Research and Development" with a Special Session on: "Methods and Tools for RNA Structure and Functional Analysis" June 10-13, 2009 Department of Computer Science, University of Catania, Italy http://www.nettab.org/2009/ Deadline approaching: May 4, 2009: Oral communication submission Contributions must be short papers of around THREE A4 pages or 12.000 characters long. Submit through the EasyChair system at: http://www.easychair.org/conferences/?conf=nettab2009 . See web site for details. Invited Speakers: Alex Bateman, Doron Betel, Tim Clark, Duncan Hull, Gabriel Valiente, Debora Marks, Gabriel Valiente Topics (see the web site for an extended list) - Collaborative Web sites, - Social networking - Open Source development - Social software for collaborative documentation development - Wikis, blogs, google docs - Ontologies collaborative development - Methods and Tools for RNA Structure and Functional Analysis Deadlines - May 4, 2009: Oral communication submission - May 15, 2009: Posters submission - May 17, 2009: Early registration Calls for SPECIAL ISSUES We plan to launch Calls for Special Issues on the themes of the workshop in peer-review journals with associated Impact factor around July for submission in September 2009. Best regards. Paolo Romano on behalf of NETTAB 2009 Chairs NETTAB '09 - Ninth International Workshop on Network Tools and Applications in Biology 10-13 June 2009, Catania, Italy http://www.nettab.org/2009/ Paolo Romano (paolo.romano at istge.it) Bioinformatics National Cancer Research Institute (IST)