Supplemental results for CODEML (seqf: codon.filter treef: tree) TREE # 1 Ancestral reconstruction by CODONML. ((((((hg18: 0.000004, panTro2: 0.012023): 0.000000, ponAbe2: 0.000004): 0.034129, calJac1: 0.033039): 0.142255, cavPor3: 0.204560): 0.012799, (canFam2: 0.120778, bosTau4: 0.149625): 0.071334): 0.184938, dasNov2: 0.034590); ((((((1, 2), 3), 4), 5), (7, 6)), 8); 9..10 10..11 11..12 12..13 13..14 14..1 14..2 13..3 12..4 11..5 10..15 15..7 15..6 9..8 tree with node labels for Rod Page's TreeView ((((((1_hg18, 2_panTro2) 14 , 3_ponAbe2) 13 , 4_calJac1) 12 , 5_cavPor3) 11 , (7_canFam2, 6_bosTau4) 15 ) 10 , 8_dasNov2) 9 ; Nodes 9 to 15 are ancestral Constant sites not listed for verbose=0 (1) Marginal reconstruction of ancestral sequences (eqn. 4 in Yang et al. 1995 Genetics 141:1641-1650). Prob of best state at each node, listed by site site Freq Data: 1 4 ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) : ATG M 0.997 (M 0.997) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) 2 1 GCT (A) GCT (A) GCT (A) GCT (A) GCT (A) GCT (A) GCT (A) GCT (A) : GCT A 1.000 (A 1.000) GCT A 1.000 (A 1.000) GCT A 1.000 (A 1.000) GCT A 1.000 (A 1.000) GCT A 1.000 (A 1.000) GCT A 1.000 (A 1.000) GCT A 1.000 (A 1.000) 3 1 GTG (V) ATG (M) GTG (V) GTG (V) GTT (V) GTT (V) GTT (V) GTT (V) : GTT V 0.999 (V 0.999) GTT V 0.999 (V 1.000) GTT V 0.999 (V 1.000) GTG V 0.994 (V 1.000) GTG V 1.000 (V 1.000) GTG V 1.000 (V 1.000) GTT V 0.999 (V 1.000) 4 1 GGG (G) GGG (G) GGG (G) GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) : GGA G 1.000 (G 1.000) GGA G 1.000 (G 1.000) GGA G 1.000 (G 1.000) GGA G 0.973 (G 1.000) GGG G 1.000 (G 1.000) GGG G 1.000 (G 1.000) GGA G 1.000 (G 1.000) 5 1 CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) CTC (L) CTT (L) CTT (L) : CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 0.973 (L 1.000) 6 1 TGT (C) TGT (C) TGT (C) TGT (C) TGT (C) TGT (C) TGT (C) TGT (C) : TGT C 1.000 (C 1.000) TGT C 1.000 (C 1.000) TGT C 1.000 (C 1.000) TGT C 1.000 (C 1.000) TGT C 1.000 (C 1.000) TGT C 1.000 (C 1.000) TGT C 1.000 (C 1.000) 7 1 AAA (K) AAA (K) AAA (K) AAA (K) AAA (K) AAA (K) AAA (K) AAA (K) : AAA K 0.999 (K 0.999) AAA K 1.000 (K 1.000) AAA K 1.000 (K 1.000) AAA K 1.000 (K 1.000) AAA K 1.000 (K 1.000) AAA K 1.000 (K 1.000) AAA K 0.999 (K 1.000) 8 1 GCC (A) GCC (A) GCC (A) GCC (A) GAT (D) GCC (A) GCC (A) GCC (A) : GCC A 1.000 (A 1.000) GCC A 0.999 (A 1.000) GCC A 0.999 (A 0.999) GCC A 1.000 (A 1.000) GCC A 1.000 (A 1.000) GCC A 1.000 (A 1.000) GCC A 1.000 (A 1.000) 9 4 ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) : ATG M 0.997 (M 0.997) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) 10 2 TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCT (S) TCT (S) : TCT S 1.000 (S 1.000) TCC S 0.933 (S 1.000) TCC S 0.933 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 0.902 (S 1.000) 11 1 CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAA (Q) CAG (Q) : CAG Q 1.000 (Q 1.000) CAG Q 0.999 (Q 1.000) CAG Q 0.999 (Q 1.000) CAG Q 1.000 (Q 1.000) CAG Q 1.000 (Q 1.000) CAG Q 1.000 (Q 1.000) CAG Q 0.926 (Q 1.000) 12 1 GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) GGA (G) GGT (G) GGG (G) : GGG G 0.999 (G 0.999) GGG G 0.995 (G 1.000) GGG G 0.995 (G 1.000) GGG G 1.000 (G 1.000) GGG G 1.000 (G 1.000) GGG G 1.000 (G 1.000) GGG G 0.569 (G 1.000) 13 3 TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) : TTG L 0.999 (L 0.999) TTG L 0.999 (L 1.000) TTG L 0.999 (L 1.000) TTG L 1.000 (L 1.000) TTG L 1.000 (L 1.000) TTG L 1.000 (L 1.000) TTG L 0.995 (L 1.000) 14 1 GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) : GTG V 0.997 (V 0.997) GTG V 0.999 (V 1.000) GTG V 0.999 (V 1.000) GTG V 1.000 (V 1.000) GTG V 1.000 (V 1.000) GTG V 1.000 (V 1.000) GTG V 0.996 (V 1.000) 15 1 ACC (T) ACC (T) ACC (T) ACC (T) ACT (T) ACC (T) ACC (T) TCC (S) : TCC S 0.722 (S 0.722) ACC T 0.999 (T 1.000) ACC T 0.999 (T 1.000) ACC T 1.000 (T 1.000) ACC T 1.000 (T 1.000) ACC T 1.000 (T 1.000) ACC T 1.000 (T 1.000) 16 1 TTC (F) TTC (F) TTC (F) TTC (F) TTT (F) TTC (F) TTC (F) TTC (F) : TTC F 0.999 (F 0.999) TTC F 0.996 (F 1.000) TTC F 0.996 (F 1.000) TTC F 1.000 (F 1.000) TTC F 1.000 (F 1.000) TTC F 1.000 (F 1.000) TTC F 0.999 (F 1.000) 17 1 AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGG (R) AGA (R) TGG (W) : TGG W 0.579 (W 0.579) AGA R 0.964 (R 1.000) AGA R 0.964 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 0.941 (R 1.000) 18 2 GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) : GAT D 0.999 (D 0.999) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 0.999 (D 1.000) 19 1 GTG (V) GTG (V) GTG (V) GTA (V) GTG (V) GTA (V) GTG (V) GTG (V) : GTG V 0.997 (V 0.997) GTG V 0.927 (V 1.000) GTG V 0.927 (V 1.000) GTG V 0.726 (V 1.000) GTG V 1.000 (V 1.000) GTG V 1.000 (V 1.000) GTG V 0.844 (V 1.000) 20 1 GCG (A) GCG (A) GCG (A) GCA (A) GCT (A) GCT (A) GCT (A) GCT (A) : GCT A 1.000 (A 1.000) GCT A 1.000 (A 1.000) GCT A 1.000 (A 1.000) GCA A 0.602 (A 1.000) GCG A 1.000 (A 1.000) GCG A 1.000 (A 1.000) GCT A 1.000 (A 1.000) 21 1 CTA (L) CTA (L) CTA (L) CTA (L) CTA (L) CTG (L) CTG (L) GTA (V) : GTA V 0.707 (V 0.707) CTA L 0.993 (L 1.000) CTA L 0.993 (L 1.000) CTA L 1.000 (L 1.000) CTA L 1.000 (L 1.000) CTA L 1.000 (L 1.000) CTG L 0.829 (L 1.000) 22 1 GAC (D) GAC (D) GAC (D) GAC (D) GAC (D) AAT (N) GAT (D) GAC (D) : GAC D 0.999 (D 0.999) GAC D 0.988 (D 1.000) GAC D 0.988 (D 1.000) GAC D 1.000 (D 1.000) GAC D 1.000 (D 1.000) GAC D 1.000 (D 1.000) GAT D 0.867 (D 1.000) 23 1 TTT (F) TTT (F) TTT (F) TTT (F) TTT (F) TTT (F) TTT (F) TTT (F) : TTT F 1.000 (F 1.000) TTT F 1.000 (F 1.000) TTT F 1.000 (F 1.000) TTT F 1.000 (F 1.000) TTT F 1.000 (F 1.000) TTT F 1.000 (F 1.000) TTT F 1.000 (F 1.000) 24 2 TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCT (S) TCT (S) : TCT S 1.000 (S 1.000) TCC S 0.933 (S 1.000) TCC S 0.933 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 0.902 (S 1.000) 25 2 CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) : CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) 26 1 GAA (E) GAA (E) GAA (E) GAA (E) GAG (E) GAG (E) GAG (E) GAG (E) : GAG E 0.997 (E 0.997) GAG E 0.961 (E 1.000) GAG E 0.961 (E 1.000) GAA E 0.992 (E 1.000) GAA E 1.000 (E 1.000) GAA E 1.000 (E 1.000) GAG E 0.988 (E 1.000) 27 1 GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAA (E) GAA (E) GAG (E) : GAG E 0.997 (E 0.997) GAG E 0.959 (E 1.000) GAG E 0.959 (E 1.000) GAG E 0.999 (E 1.000) GAG E 1.000 (E 1.000) GAG E 1.000 (E 1.000) GAA E 0.833 (E 1.000) 28 4 TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) : TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) 29 1 GAA (E) GAA (E) GAA (E) GAA (E) GAA (E) GAA (E) GAA (E) GAA (E) : GAA E 0.999 (E 0.999) GAA E 1.000 (E 1.000) GAA E 1.000 (E 1.000) GAA E 1.000 (E 1.000) GAA E 1.000 (E 1.000) GAA E 1.000 (E 1.000) GAA E 0.998 (E 1.000) 30 4 TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) : TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) 31 1 CTG (L) CTG (L) CTG (L) CTG (L) CTT (L) CTG (L) CTG (L) CTG (L) : CTG L 1.000 (L 1.000) CTG L 0.999 (L 1.000) CTG L 0.999 (L 1.000) CTG L 1.000 (L 1.000) CTG L 1.000 (L 1.000) CTG L 1.000 (L 1.000) CTG L 0.997 (L 1.000) 32 1 AAG (K) AAG (K) AAG (K) AAG (K) GCT (A) GAC (D) GAT (D) GAT (D) : GAT D 0.999 (D 0.999) GAT D 0.993 (D 1.000) GAT D 0.982 (D 0.988) AAG K 0.999 (K 1.000) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) GAT D 0.945 (D 1.000) 33 1 CCA (P) CCA (P) CCA (P) CCA (P) CCG (P) TCA (S) CCA (P) CCA (P) : CCA P 1.000 (P 1.000) CCA P 1.000 (P 1.000) CCA P 1.000 (P 1.000) CCA P 1.000 (P 1.000) CCA P 1.000 (P 1.000) CCA P 1.000 (P 1.000) CCA P 1.000 (P 1.000) 34 2 TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) : TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) 35 1 CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) : CAG Q 1.000 (Q 1.000) CAG Q 1.000 (Q 1.000) CAG Q 1.000 (Q 1.000) CAG Q 1.000 (Q 1.000) CAG Q 1.000 (Q 1.000) CAG Q 1.000 (Q 1.000) CAG Q 0.999 (Q 1.000) 36 1 AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AGG (R) : AGG R 0.727 (R 0.727) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 0.998 (K 1.000) 37 2 GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) : GAT D 0.999 (D 0.999) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 0.999 (D 1.000) 38 1 TTA (L) TTA (L) TTA (L) TTA (L) TTA (L) TTG (L) TTA (L) TTA (L) : TTA L 1.000 (L 1.000) TTA L 0.999 (L 1.000) TTA L 0.999 (L 1.000) TTA L 1.000 (L 1.000) TTA L 1.000 (L 1.000) TTA L 1.000 (L 1.000) TTA L 0.945 (L 1.000) 39 2 TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) : TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) 40 1 AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) : AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) 41 1 GAT (D) GAT (D) GAT (D) GAT (D) GAA (E) GAT (D) GAC (D) GAT (D) : GAT D 0.999 (D 0.999) GAT D 0.993 (D 1.000) GAT D 0.992 (D 0.999) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 1.000 (D 1.000) GAT D 0.930 (D 1.000) 42 1 GTC (V) GTC (V) GTC (V) GTC (V) GTC (V) GTC (V) GTC (V) GTC (V) : GTC V 0.999 (V 0.999) GTC V 1.000 (V 1.000) GTC V 1.000 (V 1.000) GTC V 1.000 (V 1.000) GTC V 1.000 (V 1.000) GTC V 1.000 (V 1.000) GTC V 0.999 (V 1.000) 43 1 ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ACA (T) : ACA T 0.807 (T 0.807) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) 44 3 TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) : TTG L 0.999 (L 0.999) TTG L 0.999 (L 1.000) TTG L 0.999 (L 1.000) TTG L 1.000 (L 1.000) TTG L 1.000 (L 1.000) TTG L 1.000 (L 1.000) TTG L 0.995 (L 1.000) 45 1 GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) : GAG E 0.997 (E 0.997) GAG E 0.999 (E 1.000) GAG E 0.999 (E 1.000) GAG E 1.000 (E 1.000) GAG E 1.000 (E 1.000) GAG E 1.000 (E 1.000) GAG E 0.997 (E 1.000) 46 2 AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) : AAC N 0.999 (N 0.999) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) 47 2 TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) : TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) TAC Y 1.000 (Y 1.000) 48 1 AGG (R) AGG (R) AGG (R) AGG (R) AGG (R) AGG (R) AGG (R) AGG (R) : AGG R 0.999 (R 0.999) AGG R 1.000 (R 1.000) AGG R 1.000 (R 1.000) AGG R 1.000 (R 1.000) AGG R 1.000 (R 1.000) AGG R 1.000 (R 1.000) AGG R 1.000 (R 1.000) 49 2 AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) : AAC N 0.999 (N 0.999) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) 50 3 TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) : TTG L 0.999 (L 0.999) TTG L 0.999 (L 1.000) TTG L 0.999 (L 1.000) TTG L 1.000 (L 1.000) TTG L 1.000 (L 1.000) TTG L 1.000 (L 1.000) TTG L 0.995 (L 1.000) 51 1 GTA (V) GTA (V) GTA (V) GTA (V) GTA (V) GTA (V) GTA (V) GTA (V) : GTA V 0.999 (V 0.999) GTA V 1.000 (V 1.000) GTA V 1.000 (V 1.000) GTA V 1.000 (V 1.000) GTA V 1.000 (V 1.000) GTA V 1.000 (V 1.000) GTA V 0.998 (V 1.000) 52 4 TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) : TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) 53 1 CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) : CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) CTT L 1.000 (L 1.000) 54 1 GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) : GGA G 1.000 (G 1.000) GGA G 1.000 (G 1.000) GGA G 1.000 (G 1.000) GGA G 1.000 (G 1.000) GGA G 1.000 (G 1.000) GGA G 1.000 (G 1.000) GGA G 1.000 (G 1.000) 55 1 CTC (L) CTC (L) CTC (L) CTC (L) CTC (L) CTC (L) CTC (L) CTC (L) : CTC L 1.000 (L 1.000) CTC L 1.000 (L 1.000) CTC L 1.000 (L 1.000) CTC L 1.000 (L 1.000) CTC L 1.000 (L 1.000) CTC L 1.000 (L 1.000) CTC L 1.000 (L 1.000) 56 1 TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) : TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) 57 1 ATT (I) ATT (I) ATT (I) TTT (F) ATT (I) ATT (I) ATT (I) ATT (I) : ATT I 1.000 (I 1.000) ATT I 1.000 (I 1.000) ATT I 1.000 (I 1.000) ATT I 1.000 (I 1.000) ATT I 1.000 (I 1.000) ATT I 1.000 (I 1.000) ATT I 1.000 (I 1.000) 58 2 TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) : TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) TCT S 1.000 (S 1.000) 59 1 AAG (K) AAG (K) AAG (K) AAG (K) AAA (K) AAG (K) AAG (K) AAA (K) : AAA K 0.999 (K 0.999) AAA K 0.570 (K 1.000) AAA K 0.570 (K 1.000) AAG K 0.993 (K 1.000) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 0.877 (K 1.000) 60 1 CCC (P) CCC (P) CCC (P) CCC (P) CCC (P) CCC (P) CCC (P) CCC (P) : CCC P 1.000 (P 1.000) CCC P 1.000 (P 1.000) CCC P 1.000 (P 1.000) CCC P 1.000 (P 1.000) CCC P 1.000 (P 1.000) CCC P 1.000 (P 1.000) CCC P 1.000 (P 1.000) 61 1 AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AGC (S) : AGC S 0.730 (S 0.730) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) AAC N 1.000 (N 1.000) 62 4 ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) : ATG M 0.997 (M 0.997) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) 63 1 ATC (I) ATC (I) ATC (I) ATC (I) ATC (I) ATC (I) ATC (I) ATC (I) : ATC I 0.999 (I 0.999) ATC I 1.000 (I 1.000) ATC I 1.000 (I 1.000) ATC I 1.000 (I 1.000) ATC I 1.000 (I 1.000) ATC I 1.000 (I 1.000) ATC I 1.000 (I 1.000) 64 1 TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) ACC (T) : ACC T 0.721 (T 0.721) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) TCC S 1.000 (S 1.000) 65 1 TTA (L) TTA (L) TTA (L) TTA (L) TTA (L) TTA (L) TTG (L) TTA (L) : TTA L 1.000 (L 1.000) TTA L 0.999 (L 1.000) TTA L 0.999 (L 1.000) TTA L 1.000 (L 1.000) TTA L 1.000 (L 1.000) TTA L 1.000 (L 1.000) TTA L 0.930 (L 1.000) 66 1 CTG (L) CTG (L) CTG (L) CTG (L) TTG (L) TTG (L) TTG (L) CTG (L) : CTG L 0.999 (L 0.999) CTG L 0.663 (L 1.000) CTG L 0.663 (L 1.000) CTG L 0.997 (L 1.000) CTG L 1.000 (L 1.000) CTG L 1.000 (L 1.000) TTG L 0.849 (L 1.000) 67 1 GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAA (E) GAG (E) GAA (E) : GAA E 0.998 (E 0.999) GAG E 0.758 (E 1.000) GAG E 0.758 (E 1.000) GAG E 0.996 (E 1.000) GAG E 1.000 (E 1.000) GAG E 1.000 (E 1.000) GAG E 0.706 (E 1.000) 68 2 CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) : CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) CAA Q 1.000 (Q 1.000) 69 1 GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) : GGG G 0.999 (G 0.999) GGG G 1.000 (G 1.000) GGG G 1.000 (G 1.000) GGG G 1.000 (G 1.000) GGG G 1.000 (G 1.000) GGG G 1.000 (G 1.000) GGG G 1.000 (G 1.000) 70 1 AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) : AAG K 0.998 (K 0.998) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 0.998 (K 1.000) 71 1 GAA (E) GAA (E) GAA (E) GAA (E) GAG (E) GAA (E) GAA (E) GAG (E) : GAG E 0.997 (E 0.997) GAA E 0.722 (E 1.000) GAA E 0.722 (E 1.000) GAA E 0.998 (E 1.000) GAA E 1.000 (E 1.000) GAA E 1.000 (E 1.000) GAA E 0.950 (E 1.000) 72 1 CCG (P) CCG (P) CCG (P) CCA (P) CCC (P) CCT (P) CCC (P) CCT (P) : CCT P 1.000 (P 1.000) CCT P 0.574 (P 1.000) CCT P 0.574 (P 1.000) CCA P 0.603 (P 1.000) CCG P 1.000 (P 1.000) CCG P 1.000 (P 1.000) CCT P 0.571 (P 1.000) 73 4 TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) : TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) TGG W 1.000 (W 1.000) 74 4 ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) : ATG M 0.997 (M 0.997) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) 75 1 GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) ATG (M) : ATG M 0.729 (M 0.729) GTG V 0.999 (V 1.000) GTG V 0.999 (V 1.000) GTG V 1.000 (V 1.000) GTG V 1.000 (V 1.000) GTG V 1.000 (V 1.000) GTG V 0.997 (V 1.000) 76 1 GAG (E) GAG (E) GAG (E) GAG (E) CAA (Q) GAG (E) GAG (E) GAA (E) : GAA E 0.999 (E 0.999) GAA E 0.565 (E 1.000) GAA E 0.565 (E 0.999) GAG E 0.992 (E 1.000) GAG E 1.000 (E 1.000) GAG E 1.000 (E 1.000) GAG E 0.862 (E 1.000) 77 1 AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AAA (K) AGA (R) : AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) AGA R 1.000 (R 1.000) 78 1 AAG (K) AAG (K) AAG (K) AAG (K) GAG (E) GAG (E) GAG (E) GAG (E) : GAG E 0.997 (E 0.997) GAG E 1.000 (E 1.000) GAG E 0.984 (E 0.985) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) AAG K 1.000 (K 1.000) GAG E 0.997 (E 1.000) 79 1 ATG (M) ATG (M) ATG (M) ATG (M) CTG (L) ATG (M) ATG (M) ATA (I) : ATA I 0.729 (I 0.729) ATG M 1.000 (M 1.000) ATG M 0.998 (M 0.998) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) ATG M 1.000 (M 1.000) 80 1 TCA (S) TCA (S) TCA (S) TCA (S) TCA (S) TCG (S) TCA (S) TCA (S) : TCA S 1.000 (S 1.000) TCA S 1.000 (S 1.000) TCA S 1.000 (S 1.000) TCA S 1.000 (S 1.000) TCA S 1.000 (S 1.000) TCA S 1.000 (S 1.000) TCA S 0.971 (S 1.000) 81 1 CAG (Q) CAG (Q) CAG (Q) CAG (Q) CGT (R) GAT (D) GAT (D) GAT (D) : GAT D 0.999 (D 0.999) GAT D 1.000 (D 1.000) CAT H 0.954 (H 0.954) CAG Q 1.000 (Q 1.000) CAG Q 1.000 (Q 1.000) CAG Q 1.000 (Q 1.000) GAT D 0.999 (D 1.000) Summary of changes along branches. Check root of tree for directions of change. Branch 1: 9..10 (n= 9.5 s= 5.5) 10 TCT (S) 1.000 -> TCC (S) 1.000 15 TCC (S) 0.722 -> ACC (T) 1.000 17 TGG (W) 0.579 -> AGA (R) 1.000 21 GTA (V) 0.707 -> CTA (L) 1.000 24 TCT (S) 1.000 -> TCC (S) 1.000 36 AGG (R) 0.727 -> AAG (K) 1.000 43 ACA (T) 0.807 -> ATG (M) 1.000 61 AGC (S) 0.730 -> AAC (N) 1.000 64 ACC (T) 0.721 -> TCC (S) 1.000 67 GAA (E) 0.999 -> GAG (E) 1.000 71 GAG (E) 0.997 -> GAA (E) 1.000 75 ATG (M) 0.729 -> GTG (V) 1.000 79 ATA (I) 0.729 -> ATG (M) 1.000 Branch 2: 10..11 (n= 1.0 s= 0.0) 81 GAT (D) 1.000 -> CAT (H) 0.954 Branch 3: 11..12 (n= 4.0 s= 6.0) 3 GTT (V) 1.000 -> GTG (V) 1.000 20 GCT (A) 1.000 -> GCA (A) 1.000 26 GAG (E) 1.000 -> GAA (E) 1.000 32 GAT (D) 0.988 -> AAG (K) 1.000 59 AAA (K) 1.000 -> AAG (K) 1.000 72 CCT (P) 1.000 -> CCA (P) 1.000 76 GAA (E) 0.999 -> GAG (E) 1.000 78 GAG (E) 0.985 -> AAG (K) 1.000 81 CAT (H) 0.954 -> CAG (Q) 1.000 Branch 4: 12..13 (n= 0.0 s= 3.0) 4 GGA (G) 1.000 -> GGG (G) 1.000 20 GCA (A) 1.000 -> GCG (A) 1.000 72 CCA (P) 1.000 -> CCG (P) 1.000 Branch 5: 13..14 (n= 0.0 s= 0.0) Branch 6: 14..1 (hg18) (n= 0.0 s= 0.0) Branch 7: 14..2 (panTro2) (n= 1.0 s= 0.0) 3 GTG (V) 1.000 -> ATG (M) Branch 8: 13..3 (ponAbe2) (n= 0.0 s= 0.0) Branch 9: 12..4 (calJac1) (n= 1.0 s= 1.0) 19 GTG (V) 1.000 -> GTA (V) 57 ATT (I) 1.000 -> TTT (F) Branch 10: 11..5 (cavPor3) (n= 6.0 s= 8.0) 8 GCC (A) 0.999 -> GAT (D) 15 ACC (T) 1.000 -> ACT (T) 16 TTC (F) 1.000 -> TTT (F) 31 CTG (L) 1.000 -> CTT (L) 32 GAT (D) 0.988 -> GCT (A) 33 CCA (P) 1.000 -> CCG (P) 41 GAT (D) 0.999 -> GAA (E) 66 CTG (L) 1.000 -> TTG (L) 71 GAA (E) 1.000 -> GAG (E) 72 CCT (P) 1.000 -> CCC (P) 76 GAA (E) 0.999 -> CAA (Q) 79 ATG (M) 0.998 -> CTG (L) 81 CAT (H) 0.954 -> CGT (R) Branch 11: 10..15 (n= 0.0 s= 6.0) 21 CTA (L) 1.000 -> CTG (L) 1.000 22 GAC (D) 1.000 -> GAT (D) 1.000 27 GAG (E) 1.000 -> GAA (E) 1.000 59 AAA (K) 1.000 -> AAG (K) 1.000 66 CTG (L) 1.000 -> TTG (L) 1.000 76 GAA (E) 1.000 -> GAG (E) 1.000 Branch 12: 15..7 (canFam2) (n= 1.0 s= 7.0) 10 TCC (S) 1.000 -> TCT (S) 11 CAG (Q) 1.000 -> CAA (Q) 12 GGG (G) 1.000 -> GGT (G) 24 TCC (S) 1.000 -> TCT (S) 41 GAT (D) 1.000 -> GAC (D) 65 TTA (L) 1.000 -> TTG (L) 72 CCT (P) 1.000 -> CCC (P) 77 AGA (R) 1.000 -> AAA (K) Branch 13: 15..6 (bosTau4) (n= 2.0 s= 8.0) 5 CTT (L) 1.000 -> CTC (L) 12 GGG (G) 1.000 -> GGA (G) 17 AGA (R) 1.000 -> AGG (R) 19 GTG (V) 1.000 -> GTA (V) 22 GAT (D) 1.000 -> AAT (N) 32 GAT (D) 1.000 -> GAC (D) 33 CCA (P) 1.000 -> TCA (S) 38 TTA (L) 1.000 -> TTG (L) 67 GAG (E) 1.000 -> GAA (E) 80 TCA (S) 1.000 -> TCG (S) Branch 14: 9..8 (dasNov2) (n= 0.0 s= 0.0) List of extant and reconstructed sequences 15 243 hg18 ATG GCT GTG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG panTro2 ATG GCT ATG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG ponAbe2 ATG GCT GTG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG calJac1 ATG GCT GTG GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTA GCA CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC TTT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCA TGG ATG GTG GAG AGA AAG ATG TCA CAG cavPor3 ATG GCT GTT GGA CTT TGT AAA GAT ATG TCC CAG GGG TTG GTG ACT TTT AGA GAT GTG GCT CTA GAC TTT TCC CAA GAG GAG TGG GAA TGG CTT GCT CCG TCT CAG AAG GAT TTA TAC AGA GAA GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AAC ATG ATC TCC TTA TTG GAG CAA GGG AAG GAG CCC TGG ATG GTG CAA AGA GAG CTG TCA CGT bosTau4 ATG GCT GTT GGA CTC TGT AAA GCC ATG TCC CAG GGA TTG GTG ACC TTC AGG GAT GTA GCT CTG AAT TTT TCC CAA GAG GAA TGG GAA TGG CTG GAC TCA TCT CAG AAG GAT TTG TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA TTG GAA CAA GGG AAG GAA CCT TGG ATG GTG GAG AGA GAG ATG TCG GAT canFam2 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCT CAA GGT TTG GTG ACC TTC AGA GAT GTG GCT CTG GAT TTT TCT CAA GAG GAA TGG GAA TGG CTG GAT CCA TCT CAG AAG GAT TTA TAC AGA GAC GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTG TTG GAG CAA GGG AAG GAA CCC TGG ATG GTG GAG AAA GAG ATG TCA GAT dasNov2 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCT CAG GGG TTG GTG TCC TTC TGG GAT GTG GCT GTA GAC TTT TCT CAA GAG GAG TGG GAA TGG CTG GAT CCA TCT CAG AGG GAT TTA TAC AGA GAT GTC ACA TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AGC ATG ATC ACC TTA CTG GAA CAA GGG AAG GAG CCT TGG ATG ATG GAA AGA GAG ATA TCA GAT node #9 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCT CAG GGG TTG GTG TCC TTC TGG GAT GTG GCT GTA GAC TTT TCT CAA GAG GAG TGG GAA TGG CTG GAT CCA TCT CAG AGG GAT TTA TAC AGA GAT GTC ACA TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AGC ATG ATC ACC TTA CTG GAA CAA GGG AAG GAG CCT TGG ATG ATG GAA AGA GAG ATA TCA GAT node #10 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCT CTA GAC TTT TCC CAA GAG GAG TGG GAA TGG CTG GAT CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCT TGG ATG GTG GAA AGA GAG ATG TCA GAT node #11 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCT CTA GAC TTT TCC CAA GAG GAG TGG GAA TGG CTG GAT CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCT TGG ATG GTG GAA AGA GAG ATG TCA CAT node #12 ATG GCT GTG GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCA CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCA TGG ATG GTG GAG AGA AAG ATG TCA CAG node #13 ATG GCT GTG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG node #14 ATG GCT GTG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG node #15 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCT CTG GAT TTT TCC CAA GAG GAA TGG GAA TGG CTG GAT CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA TTG GAG CAA GGG AAG GAA CCT TGG ATG GTG GAG AGA GAG ATG TCA GAT Overall accuracy of the 7 ancestral sequences: 0.96770 0.96881 0.96787 0.98595 1.00000 1.00000 0.96367 for a site. 0.04534 0.04549 0.04208 0.24588 1.00000 1.00000 0.03426 for the sequence. Amino acid sequences inferred by codonml. Node #9 MAVGLCKAMS QGLVSFWDVA VDFSQEEWEW LDPSQRDLYR DVTLENYRNL VWLGLSISKP SMITLLEQGK EPWMMEREIS D Node #10 MAVGLCKAMS QGLVTFRDVA LDFSQEEWEW LDPSQKDLYR DVMLENYRNL VWLGLSISKP NMISLLEQGK EPWMVEREMS D Node #11 MAVGLCKAMS QGLVTFRDVA LDFSQEEWEW LDPSQKDLYR DVMLENYRNL VWLGLSISKP NMISLLEQGK EPWMVEREMS H Node #12 MAVGLCKAMS QGLVTFRDVA LDFSQEEWEW LKPSQKDLYR DVMLENYRNL VWLGLSISKP NMISLLEQGK EPWMVERKMS Q Node #13 MAVGLCKAMS QGLVTFRDVA LDFSQEEWEW LKPSQKDLYR DVMLENYRNL VWLGLSISKP NMISLLEQGK EPWMVERKMS Q Node #14 MAVGLCKAMS QGLVTFRDVA LDFSQEEWEW LKPSQKDLYR DVMLENYRNL VWLGLSISKP NMISLLEQGK EPWMVERKMS Q Node #15 MAVGLCKAMS QGLVTFRDVA LDFSQEEWEW LDPSQKDLYR DVMLENYRNL VWLGLSISKP NMISLLEQGK EPWMVEREMS D Counts of changes at sites, listed by site 1 (S N: 0.000 3.000 Sd Nd: 0.0 0.0) 2 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 3 GTG.ATG GTT.GTG (S N: 0.994 2.006 Sd Nd: 1.0 1.0) 4 GGA.GGG (S N: 1.121 1.879 Sd Nd: 1.0 0.0) 5 CTT.CTC (S N: 1.000 2.000 Sd Nd: 1.0 0.0) 6 (S N: 0.375 2.625 Sd Nd: 0.0 0.0) 7 (S N: 0.375 2.625 Sd Nd: 0.0 0.0) 8 GCC.GAT (S N: 0.932 2.068 Sd Nd: 1.0 1.0) 9 (S N: 0.000 3.000 Sd Nd: 0.0 0.0) 10 TCC.TCT TCT.TCC (S N: 1.000 2.000 Sd Nd: 2.0 0.0) 11 CAG.CAA (S N: 0.375 2.625 Sd Nd: 1.0 0.0) 12 GGG.GGA GGG.GGT (S N: 1.008 1.992 Sd Nd: 2.0 0.0) 13 (S N: 0.750 2.250 Sd Nd: 0.0 0.0) 14 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 15 ACC.ACT TCC.ACC (S N: 1.000 2.000 Sd Nd: 1.0 1.0) 16 TTC.TTT (S N: 0.333 2.667 Sd Nd: 1.0 0.0) 17 AGA.AGG TGG.AGA (S N: 0.659 2.341 Sd Nd: 2.0 1.0) 18 (S N: 0.333 2.667 Sd Nd: 0.0 0.0) 19 GTG.GTA GTG.GTA (S N: 1.000 2.000 Sd Nd: 2.0 0.0) 20 GCT.GCA GCA.GCG (S N: 1.000 2.000 Sd Nd: 2.0 0.0) 21 GTA.CTA CTA.CTG (S N: 1.291 1.709 Sd Nd: 1.0 1.0) 22 GAT.AAT GAC.GAT (S N: 0.333 2.667 Sd Nd: 1.0 1.0) 23 (S N: 0.333 2.667 Sd Nd: 0.0 0.0) 24 TCC.TCT TCT.TCC (S N: 1.000 2.000 Sd Nd: 2.0 0.0) 25 (S N: 0.375 2.625 Sd Nd: 0.0 0.0) 26 GAG.GAA (S N: 0.375 2.625 Sd Nd: 1.0 0.0) 27 GAG.GAA (S N: 0.375 2.625 Sd Nd: 1.0 0.0) 28 (S N: 0.000 3.000 Sd Nd: 0.0 0.0) 29 (S N: 0.375 2.625 Sd Nd: 0.0 0.0) 30 (S N: 0.000 3.000 Sd Nd: 0.0 0.0) 31 CTG.CTT (S N: 1.299 1.701 Sd Nd: 1.0 0.0) 32 GAT.GCT GAT.GAC GAT.AAG (S N: 0.408 2.592 Sd Nd: 1.0 3.0) 33 CCA.CCG CCA.TCA (S N: 1.017 1.983 Sd Nd: 1.0 1.0) 34 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 35 (S N: 0.375 2.625 Sd Nd: 0.0 0.0) 36 AGG.AAG (S N: 0.416 2.584 Sd Nd: 0.0 1.0) 37 (S N: 0.333 2.667 Sd Nd: 0.0 0.0) 38 TTA.TTG (S N: 0.848 2.152 Sd Nd: 1.0 0.0) 39 (S N: 0.429 2.571 Sd Nd: 0.0 0.0) 40 (S N: 0.750 2.250 Sd Nd: 0.0 0.0) 41 GAT.GAA GAT.GAC (S N: 0.337 2.663 Sd Nd: 1.0 1.0) 42 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 43 ACA.ATG (S N: 0.127 2.873 Sd Nd: 0.5 1.5) 44 (S N: 0.750 2.250 Sd Nd: 0.0 0.0) 45 (S N: 0.375 2.625 Sd Nd: 0.0 0.0) 46 (S N: 0.333 2.667 Sd Nd: 0.0 0.0) 47 (S N: 0.429 2.571 Sd Nd: 0.0 0.0) 48 (S N: 0.667 2.333 Sd Nd: 0.0 0.0) 49 (S N: 0.333 2.667 Sd Nd: 0.0 0.0) 50 (S N: 0.750 2.250 Sd Nd: 0.0 0.0) 51 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 52 (S N: 0.000 3.000 Sd Nd: 0.0 0.0) 53 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 54 (S N: 1.125 1.875 Sd Nd: 0.0 0.0) 55 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 56 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 57 ATT.TTT (S N: 0.661 2.339 Sd Nd: 0.0 1.0) 58 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 59 AAA.AAG AAA.AAG (S N: 0.375 2.625 Sd Nd: 2.0 0.0) 60 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 61 AGC.AAC (S N: 0.333 2.667 Sd Nd: 0.0 1.0) 62 (S N: 0.000 3.000 Sd Nd: 0.0 0.0) 63 (S N: 0.667 2.333 Sd Nd: 0.0 0.0) 64 ACC.TCC (S N: 1.000 2.000 Sd Nd: 0.0 1.0) 65 TTA.TTG (S N: 0.850 2.150 Sd Nd: 1.0 0.0) 66 CTG.TTG CTG.TTG (S N: 1.112 1.888 Sd Nd: 2.0 0.0) 67 GAG.GAA GAA.GAG (S N: 0.375 2.625 Sd Nd: 2.0 0.0) 68 (S N: 0.375 2.625 Sd Nd: 0.0 0.0) 69 (S N: 1.000 2.000 Sd Nd: 0.0 0.0) 70 (S N: 0.375 2.625 Sd Nd: 0.0 0.0) 71 GAA.GAG GAG.GAA (S N: 0.375 2.625 Sd Nd: 2.0 0.0) 72 CCT.CCC CCT.CCC CCT.CCA CCA.CCG (S N: 1.000 2.000 Sd Nd: 4.0 0.0) 73 (S N: 0.000 3.000 Sd Nd: 0.0 0.0) 74 (S N: 0.000 3.000 Sd Nd: 0.0 0.0) 75 ATG.GTG (S N: 0.873 2.127 Sd Nd: 0.0 1.0) 76 GAA.CAA GAA.GAG GAA.GAG (S N: 0.375 2.625 Sd Nd: 2.0 1.0) 77 AGA.AAA (S N: 0.727 2.273 Sd Nd: 0.0 1.0) 78 GAG.AAG (S N: 0.375 2.625 Sd Nd: 0.0 1.0) 79 ATG.CTG ATA.ATG (S N: 0.221 2.779 Sd Nd: 0.0 2.0) 80 TCA.TCG (S N: 1.272 1.728 Sd Nd: 1.0 0.0) 81 CAT.CGT GAT.CAT CAT.CAG (S N: 0.408 2.592 Sd Nd: 0.0 3.0) (2) Joint reconstruction of ancestral sequences (eqn. 2 in Yang et al. 1995 Genetics 141:1641-1650), using the algorithm of Pupko et al. (2000 Mol Biol Evol 17:890-896). Reconstruction (prob.), listed by pattern Pattern Freq Data: 1 4 ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) : ATG ATG ATG ATG ATG ATG ATG (0.997) GTG ATG ATG ATG ATG ATG ATG (0.001) ACG ATG ATG ATG ATG ATG ATG (0.001) ATA ATG ATG ATG ATG ATG ATG (0.001) TTG ATG ATG ATG ATG ATG ATG (0.000) AAG ATG ATG ATG ATG ATG ATG (0.000) (total 1.000) 2 1 GCT (A) GCT (A) GCT (A) GCT (A) GCT (A) GCT (A) GCT (A) GCT (A) : GCT GCT GCT GCT GCT GCT GCT (1.000) GTT GCT GCT GCT GCT GCT GCT (0.000) GCT GCT GCT GCT GCT GCT GCC (0.000) ACT GCT GCT GCT GCT GCT GCT (0.000) GAT GCT GCT GCT GCT GCT GCT (0.000) GCT GCT GCT GCC GCT GCT GCT (0.000) (total 1.000) 3 1 GTG (V) ATG (M) GTG (V) GTG (V) GTT (V) GTT (V) GTT (V) GTT (V) : GTT GTT GTT GTG GTG GTG GTT (0.992) GTT GTT GTT GTT GTG GTG GTT (0.004) GTT GTT GTT GTA GTG GTG GTT (0.001) GTT GTT GTT GTG GTG GTG GTC (0.001) ATT GTT GTT GTG GTG GTG GTT (0.000) GCT GTT GTT GTG GTG GTG GTT (0.000) (total 0.998) 4 1 GGG (G) GGG (G) GGG (G) GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) : GGA GGA GGA GGA GGG GGG GGA (0.973) GGA GGA GGA GGG GGG GGG GGA (0.027) GGA GGA GGA GGA GGG GGG GGG (0.000) GAA GGA GGA GGA GGG GGG GGA (0.000) AGA GGA GGA GGA GGG GGG GGA (0.000) GGA GGG GGG GGG GGG GGG GGA (0.000) (total 1.000) 5 1 CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) CTC (L) CTT (L) CTT (L) : CTT CTT CTT CTT CTT CTT CTT (0.973) CTT CTT CTT CTT CTT CTT CTC (0.027) TTT CTT CTT CTT CTT CTT CTT (0.000) CTT CTC CTC CTT CTT CTT CTC (0.000) CTT CTT CTT CTT CTT CTT CTG (0.000) CCT CTT CTT CTT CTT CTT CTT (0.000) (total 1.000) 6 1 TGT (C) TGT (C) TGT (C) TGT (C) TGT (C) TGT (C) TGT (C) TGT (C) : TGT TGT TGT TGT TGT TGT TGT (1.000) TAT TGT TGT TGT TGT TGT TGT (0.000) TGT TGT TGT TGT TGT TGT TGC (0.000) CGT TGT TGT TGT TGT TGT TGT (0.000) TGG TGT TGT TGT TGT TGT TGT (0.000) TTT TGT TGT TGT TGT TGT TGT (0.000) (total 1.000) 7 1 AAA (K) AAA (K) AAA (K) AAA (K) AAA (K) AAA (K) AAA (K) AAA (K) : AAA AAA AAA AAA AAA AAA AAA (0.998) AAA AAA AAA AAA AAA AAA AAG (0.001) GAA AAA AAA AAA AAA AAA AAA (0.000) AGA AAA AAA AAA AAA AAA AAA (0.000) AAA AAG AAG AAA AAA AAA AAA (0.000) AAA AAA AAA AAG AAA AAA AAA (0.000) (total 1.000) 8 1 GCC (A) GCC (A) GCC (A) GCC (A) GAT (D) GCC (A) GCC (A) GCC (A) : GCC GCC GCC GCC GCC GCC GCC (0.998) GCC GCT GCT GCC GCC GCC GCC (0.001) GCC GCC GAC GCC GCC GCC GCC (0.001) GTC GCC GCC GCC GCC GCC GCC (0.000) GCC GCC GCC GCC GCC GCC GCT (0.000) ACC GCC GCC GCC GCC GCC GCC (0.000) (total 1.000) 9 2 TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCT (S) TCT (S) : TCT TCC TCC TCC TCC TCC TCC (0.900) TCT TCT TCT TCC TCC TCC TCT (0.065) TCT TCC TCC TCC TCC TCC TCT (0.032) TCT TCT TCT TCC TCC TCC TCC (0.002) TTT TCC TCC TCC TCC TCC TCC (0.000) TCC TCC TCC TCC TCC TCC TCC (0.000) (total 1.000) 10 1 CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAA (Q) CAG (Q) : CAG CAG CAG CAG CAG CAG CAG (0.926) CAG CAG CAG CAG CAG CAG CAA (0.073) CAG CAA CAA CAG CAG CAG CAA (0.001) CGG CAG CAG CAG CAG CAG CAG (0.000) GAG CAG CAG CAG CAG CAG CAG (0.000) AAG CAG CAG CAG CAG CAG CAG (0.000) (total 1.000) 11 1 GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) GGA (G) GGT (G) GGG (G) : GGG GGG GGG GGG GGG GGG GGG (0.568) GGG GGG GGG GGG GGG GGG GGA (0.316) GGG GGG GGG GGG GGG GGG GGT (0.105) GGG GGG GGG GGG GGG GGG GGC (0.005) GAG GGG GGG GGG GGG GGG GGG (0.000) GAG GGG GGG GGG GGG GGG GGA (0.000) (total 0.995) 12 3 TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) TTG (L) : TTG TTG TTG TTG TTG TTG TTG (0.993) TTG TTG TTG TTG TTG TTG CTG (0.003) TTG TTG TTG TTG TTG TTG TTA (0.002) TCG TTG TTG TTG TTG TTG TTG (0.001) TTG CTG CTG TTG TTG TTG TTG (0.000) GTG TTG TTG TTG TTG TTG TTG (0.000) (total 0.999) 13 1 GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) : GTG GTG GTG GTG GTG GTG GTG (0.993) GTG GTG GTG GTG GTG GTG GTA (0.003) ATG GTG GTG GTG GTG GTG GTG (0.002) GCG GTG GTG GTG GTG GTG GTG (0.001) GTG GTA GTA GTG GTG GTG GTG (0.001) GTG GTG GTG GTA GTG GTG GTG (0.000) (total 0.999) 14 1 ACC (T) ACC (T) ACC (T) ACC (T) ACT (T) ACC (T) ACC (T) TCC (S) : TCC ACC ACC ACC ACC ACC ACC (0.721) ACC ACC ACC ACC ACC ACC ACC (0.270) GCC ACC ACC ACC ACC ACC ACC (0.005) CCC ACC ACC ACC ACC ACC ACC (0.003) TCC ACT ACT ACC ACC ACC ACC (0.001) ACC ACT ACT ACC ACC ACC ACC (0.000) (total 1.000) 15 1 TTC (F) TTC (F) TTC (F) TTC (F) TTT (F) TTC (F) TTC (F) TTC (F) : TTC TTC TTC TTC TTC TTC TTC (0.995) TTC TTT TTT TTC TTC TTC TTC (0.003) TTC TTT TTT TTC TTC TTC TTT (0.001) TTC TTC TTC TTC TTC TTC TTT (0.000) CTC TTC TTC TTC TTC TTC TTC (0.000) TCC TTC TTC TTC TTC TTC TTC (0.000) (total 1.000) 16 1 AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGG (R) AGA (R) TGG (W) : TGG AGA AGA AGA AGA AGA AGA (0.538) AGG AGA AGA AGA AGA AGA AGA (0.378) TGG AGG AGG AGA AGA AGA AGG (0.025) TGG AGA AGA AGA AGA AGA AGG (0.014) CGG AGA AGA AGA AGA AGA AGA (0.012) GGG AGA AGA AGA AGA AGA AGA (0.010) AGG AGA AGA AGA AGA AGA AGG (0.010) AGG AGG AGG AGA AGA AGA AGG (0.009) TGG AGG AGG AGA AGA AGA AGA (0.002) AGG AGG AGG AGA AGA AGA AGA (0.001) (total 0.998) 17 2 GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) GAT (D) : GAT GAT GAT GAT GAT GAT GAT (0.999) GAT GAT GAT GAT GAT GAT GAC (0.001) AAT GAT GAT GAT GAT GAT GAT (0.000) GGT GAT GAT GAT GAT GAT GAT (0.000) GAG GAT GAT GAT GAT GAT GAT (0.000) GAT GAT GAT GAC GAT GAT GAT (0.000) (total 1.000) 18 1 GTG (V) GTG (V) GTG (V) GTA (V) GTG (V) GTA (V) GTG (V) GTG (V) : GTG GTG GTG GTG GTG GTG GTG (0.650) GTG GTG GTG GTA GTG GTG GTG (0.184) GTG GTG GTG GTG GTG GTG GTA (0.069) GTG GTA GTA GTA GTG GTG GTA (0.063) ATG GTG GTG GTG GTG GTG GTG (0.001) GCG GTG GTG GTG GTG GTG GTG (0.001) (total 0.969) 19 1 GCG (A) GCG (A) GCG (A) GCA (A) GCT (A) GCT (A) GCT (A) GCT (A) : GCT GCT GCT GCA GCG GCG GCT (0.602) GCT GCT GCT GCG GCG GCG GCT (0.360) GCT GCT GCT GCT GCG GCG GCT (0.035) GCT GCT GCT GCC GCG GCG GCT (0.002) GTT GCT GCT GCA GCG GCG GCT (0.000) GTT GCT GCT GCG GCG GCG GCT (0.000) (total 1.000) 20 1 CTA (L) CTA (L) CTA (L) CTA (L) CTA (L) CTG (L) CTG (L) GTA (V) : GTA CTA CTA CTA CTA CTA CTG (0.581) CTA CTA CTA CTA CTA CTA CTG (0.217) GTA CTA CTA CTA CTA CTA CTA (0.119) CTA CTA CTA CTA CTA CTA CTA (0.045) TTA CTA CTA CTA CTA CTA CTG (0.017) ATA CTA CTA CTA CTA CTA CTG (0.007) GTA CTG CTG CTA CTA CTA CTG (0.005) TTA CTA CTA CTA CTA CTA CTA (0.004) ATA CTA CTA CTA CTA CTA CTA (0.001) GTA CTA CTA CTA CTA CTA TTG (0.001) (total 0.997) 21 1 GAC (D) GAC (D) GAC (D) GAC (D) GAC (D) AAT (N) GAT (D) GAC (D) : GAC GAC GAC GAC GAC GAC GAT (0.854) GAC GAC GAC GAC GAC GAC GAC (0.133) GAC GAT GAT GAC GAC GAC GAT (0.012) AAC GAC GAC GAC GAC GAC GAT (0.000) GGC GAC GAC GAC GAC GAC GAT (0.000) GAC GAT GAT GAT GAC GAC GAT (0.000) (total 1.000) 22 1 TTT (F) TTT (F) TTT (F) TTT (F) TTT (F) TTT (F) TTT (F) TTT (F) : TTT TTT TTT TTT TTT TTT TTT (0.999) TTT TTT TTT TTT TTT TTT TTC (0.000) CTT TTT TTT TTT TTT TTT TTT (0.000) TCT TTT TTT TTT TTT TTT TTT (0.000) TTG TTT TTT TTT TTT TTT TTT (0.000) TTT TTT TTT TTC TTT TTT TTT (0.000) (total 1.000) 23 2 CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) CAA (Q) : CAA CAA CAA CAA CAA CAA CAA (1.000) CAA CAA CAA CAA CAA CAA CAG (0.000) CGA CAA CAA CAA CAA CAA CAA (0.000) CAA CAA CAA CAG CAA CAA CAA (0.000) GAA CAA CAA CAA CAA CAA CAA (0.000) AAA CAA CAA CAA CAA CAA CAA (0.000) (total 1.000) 24 1 GAA (E) GAA (E) GAA (E) GAA (E) GAG (E) GAG (E) GAG (E) GAG (E) : GAG GAG GAG GAA GAA GAA GAG (0.948) GAG GAA GAA GAA GAA GAA GAG (0.029) GAG GAA GAA GAA GAA GAA GAA (0.009) GAG GAG GAG GAG GAA GAA GAG (0.008) AAG GAG GAG GAA GAA GAA GAG (0.001) GGG GAG GAG GAA GAA GAA GAG (0.001) (total 0.996) 25 1 GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAA (E) GAA (E) GAG (E) : GAG GAG GAG GAG GAG GAG GAA (0.790) GAG GAG GAG GAG GAG GAG GAG (0.166) GAG GAA GAA GAG GAG GAG GAA (0.040) AAG GAG GAG GAG GAG GAG GAA (0.001) GGG GAG GAG GAG GAG GAG GAA (0.001) GAG GAA GAA GAA GAG GAG GAA (0.001) (total 0.999) 26 4 TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) TGG (W) : TGG TGG TGG TGG TGG TGG TGG (1.000) CGG TGG TGG TGG TGG TGG TGG (0.000) TTG TGG TGG TGG TGG TGG TGG (0.000) GGG TGG TGG TGG TGG TGG TGG (0.000) TCG TGG TGG TGG TGG TGG TGG (0.000) AGG TGG TGG TGG TGG TGG TGG (0.000) (total 1.000) 27 1 GAA (E) GAA (E) GAA (E) GAA (E) GAA (E) GAA (E) GAA (E) GAA (E) : GAA GAA GAA GAA GAA GAA GAA (0.997) GAA GAA GAA GAA GAA GAA GAG (0.002) AAA GAA GAA GAA GAA GAA GAA (0.000) GGA GAA GAA GAA GAA GAA GAA (0.000) GAA GAG GAG GAA GAA GAA GAA (0.000) GAA GAA GAA GAG GAA GAA GAA (0.000) (total 1.000) 28 1 CTG (L) CTG (L) CTG (L) CTG (L) CTT (L) CTG (L) CTG (L) CTG (L) : CTG CTG CTG CTG CTG CTG CTG (0.996) CTG CTG CTG CTG CTG CTG TTG (0.002) CTG CTG CTG CTG CTG CTG CTA (0.001) CTG CTT CTT CTG CTG CTG CTG (0.001) CCG CTG CTG CTG CTG CTG CTG (0.000) GTG CTG CTG CTG CTG CTG CTG (0.000) (total 0.999) 29 1 AAG (K) AAG (K) AAG (K) AAG (K) GCT (A) GAC (D) GAT (D) GAT (D) : GAT GAT GAT AAG AAG AAG GAT (0.932) GAT GAT GAT AAG AAG AAG GAC (0.048) GAT GAT GAG AAG AAG AAG GAT (0.007) GAT GAC GAC AAG AAG AAG GAC (0.006) AAT GAT GAT AAG AAG AAG GAT (0.000) GGT GAT GAT AAG AAG AAG GAT (0.000) (total 0.993) 30 1 CCA (P) CCA (P) CCA (P) CCA (P) CCG (P) TCA (S) CCA (P) CCA (P) : CCA CCA CCA CCA CCA CCA CCA (0.999) CCA CCG CCG CCA CCA CCA CCA (0.000) CCA CCA CCA CCA CCA CCA CCG (0.000) CTA CCA CCA CCA CCA CCA CCA (0.000) TCA CCA CCA CCA CCA CCA CCA (0.000) CCA CCG CCG CCA CCA CCA CCG (0.000) (total 1.000) 31 2 TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) TCT (S) : TCT TCT TCT TCT TCT TCT TCT (1.000) TTT TCT TCT TCT TCT TCT TCT (0.000) TCT TCT TCT TCT TCT TCT TCC (0.000) CCT TCT TCT TCT TCT TCT TCT (0.000) TAT TCT TCT TCT TCT TCT TCT (0.000) GCT TCT TCT TCT TCT TCT TCT (0.000) (total 1.000) 32 1 CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) CAG (Q) : CAG CAG CAG CAG CAG CAG CAG (0.999) CAG CAG CAG CAG CAG CAG CAA (0.000) CGG CAG CAG CAG CAG CAG CAG (0.000) GAG CAG CAG CAG CAG CAG CAG (0.000) AAG CAG CAG CAG CAG CAG CAG (0.000) CAG CAA CAA CAG CAG CAG CAG (0.000) (total 1.000) 33 1 AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AGG (R) : AGG AAG AAG AAG AAG AAG AAG (0.726) AAG AAG AAG AAG AAG AAG AAG (0.269) AGG AAG AAG AAG AAG AAG AAA (0.001) ATG AAG AAG AAG AAG AAG AAG (0.001) ACG AAG AAG AAG AAG AAG AAG (0.001) AAG AAG AAG AAG AAG AAG AAA (0.001) (total 0.999) 34 1 TTA (L) TTA (L) TTA (L) TTA (L) TTA (L) TTG (L) TTA (L) TTA (L) : TTA TTA TTA TTA TTA TTA TTA (0.945) TTA TTA TTA TTA TTA TTA TTG (0.053) TTA TTG TTG TTA TTA TTA TTG (0.001) TTA TTA TTA TTA TTA TTA CTA (0.000) TCA TTA TTA TTA TTA TTA TTA (0.000) GTA TTA TTA TTA TTA TTA TTA (0.000) (total 1.000) 35 2 TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) TAC (Y) : TAC TAC TAC TAC TAC TAC TAC (0.999) TAC TAC TAC TAC TAC TAC TAT (0.000) CAC TAC TAC TAC TAC TAC TAC (0.000) TGC TAC TAC TAC TAC TAC TAC (0.000) TAC TAC TAC TAT TAC TAC TAC (0.000) TAC TAT TAT TAC TAC TAC TAC (0.000) (total 1.000) 36 1 AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) : AGA AGA AGA AGA AGA AGA AGA (1.000) AAA AGA AGA AGA AGA AGA AGA (0.000) AGA AGA AGA AGA AGA AGA AGG (0.000) GGA AGA AGA AGA AGA AGA AGA (0.000) ATA AGA AGA AGA AGA AGA AGA (0.000) AGA AGA AGA AGG AGA AGA AGA (0.000) (total 1.000) 37 1 GAT (D) GAT (D) GAT (D) GAT (D) GAA (E) GAT (D) GAC (D) GAT (D) : GAT GAT GAT GAT GAT GAT GAT (0.928) GAT GAT GAT GAT GAT GAT GAC (0.064) GAT GAC GAC GAT GAT GAT GAC (0.006) GAT GAT GAA GAT GAT GAT GAT (0.001) AAT GAT GAT GAT GAT GAT GAT (0.000) GGT GAT GAT GAT GAT GAT GAT (0.000) (total 0.999) 38 1 GTC (V) GTC (V) GTC (V) GTC (V) GTC (V) GTC (V) GTC (V) GTC (V) : GTC GTC GTC GTC GTC GTC GTC (0.998) GTC GTC GTC GTC GTC GTC GTT (0.001) ATC GTC GTC GTC GTC GTC GTC (0.000) GCC GTC GTC GTC GTC GTC GTC (0.000) GTC GTT GTT GTC GTC GTC GTC (0.000) GTC GTC GTC GTT GTC GTC GTC (0.000) (total 1.000) 39 1 ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ATG (M) ACA (T) : ACA ATG ATG ATG ATG ATG ATG (0.807) ATA ATG ATG ATG ATG ATG ATG (0.161) ATG ATG ATG ATG ATG ATG ATG (0.030) AAA ATG ATG ATG ATG ATG ATG (0.001) AGA ATG ATG ATG ATG ATG ATG (0.000) GCA ATG ATG ATG ATG ATG ATG (0.000) (total 1.000) 40 1 GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) : GAG GAG GAG GAG GAG GAG GAG (0.993) GAG GAG GAG GAG GAG GAG GAA (0.003) AAG GAG GAG GAG GAG GAG GAG (0.001) GGG GAG GAG GAG GAG GAG GAG (0.001) GAG GAA GAA GAG GAG GAG GAG (0.000) GAG GAG GAG GAA GAG GAG GAG (0.000) (total 0.999) 41 2 AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) : AAC AAC AAC AAC AAC AAC AAC (0.999) AAC AAC AAC AAC AAC AAC AAT (0.000) GAC AAC AAC AAC AAC AAC AAC (0.000) AGC AAC AAC AAC AAC AAC AAC (0.000) AAG AAC AAC AAC AAC AAC AAC (0.000) AAC AAC AAC AAT AAC AAC AAC (0.000) (total 1.000) 42 1 AGG (R) AGG (R) AGG (R) AGG (R) AGG (R) AGG (R) AGG (R) AGG (R) : AGG AGG AGG AGG AGG AGG AGG (0.999) AAG AGG AGG AGG AGG AGG AGG (0.001) GGG AGG AGG AGG AGG AGG AGG (0.000) AGG AGG AGG AGG AGG AGG AGA (0.000) ATG AGG AGG AGG AGG AGG AGG (0.000) TGG AGG AGG AGG AGG AGG AGG (0.000) (total 1.000) 43 1 GTA (V) GTA (V) GTA (V) GTA (V) GTA (V) GTA (V) GTA (V) GTA (V) : GTA GTA GTA GTA GTA GTA GTA (0.997) GTA GTA GTA GTA GTA GTA GTG (0.002) ATA GTA GTA GTA GTA GTA GTA (0.000) GCA GTA GTA GTA GTA GTA GTA (0.000) GTA GTG GTG GTA GTA GTA GTA (0.000) GTA GTA GTA GTG GTA GTA GTA (0.000) (total 1.000) 44 1 CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) CTT (L) : CTT CTT CTT CTT CTT CTT CTT (1.000) TTT CTT CTT CTT CTT CTT CTT (0.000) CTT CTT CTT CTT CTT CTT CTC (0.000) CCT CTT CTT CTT CTT CTT CTT (0.000) GTT CTT CTT CTT CTT CTT CTT (0.000) ATT CTT CTT CTT CTT CTT CTT (0.000) (total 1.000) 45 1 GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) GGA (G) : GGA GGA GGA GGA GGA GGA GGA (0.999) GGA GGA GGA GGA GGA GGA GGG (0.000) GAA GGA GGA GGA GGA GGA GGA (0.000) AGA GGA GGA GGA GGA GGA GGA (0.000) GTA GGA GGA GGA GGA GGA GGA (0.000) GGA GGA GGA GGG GGA GGA GGA (0.000) (total 1.000) 46 1 CTC (L) CTC (L) CTC (L) CTC (L) CTC (L) CTC (L) CTC (L) CTC (L) : CTC CTC CTC CTC CTC CTC CTC (1.000) TTC CTC CTC CTC CTC CTC CTC (0.000) CTC CTC CTC CTC CTC CTC CTT (0.000) CCC CTC CTC CTC CTC CTC CTC (0.000) GTC CTC CTC CTC CTC CTC CTC (0.000) ATC CTC CTC CTC CTC CTC CTC (0.000) (total 1.000) 47 1 TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) : TCC TCC TCC TCC TCC TCC TCC (1.000) TTC TCC TCC TCC TCC TCC TCC (0.000) TCC TCC TCC TCC TCC TCC TCT (0.000) CCC TCC TCC TCC TCC TCC TCC (0.000) TAC TCC TCC TCC TCC TCC TCC (0.000) GCC TCC TCC TCC TCC TCC TCC (0.000) (total 1.000) 48 1 ATT (I) ATT (I) ATT (I) TTT (F) ATT (I) ATT (I) ATT (I) ATT (I) : ATT ATT ATT ATT ATT ATT ATT (0.999) ATT ATT ATT ATT ATT ATT ATC (0.000) GTT ATT ATT ATT ATT ATT ATT (0.000) ACT ATT ATT ATT ATT ATT ATT (0.000) ATG ATT ATT ATT ATT ATT ATT (0.000) ATT ATT ATT ATC ATT ATT ATT (0.000) (total 1.000) 49 1 AAG (K) AAG (K) AAG (K) AAG (K) AAA (K) AAG (K) AAG (K) AAA (K) : AAA AAA AAA AAG AAG AAG AAG (0.442) AAA AAG AAG AAG AAG AAG AAG (0.429) AAA AAA AAA AAG AAG AAG AAA (0.121) AAA AAA AAA AAA AAG AAG AAG (0.005) GAA AAG AAG AAG AAG AAG AAG (0.000) GAA AAA AAA AAG AAG AAG AAG (0.000) (total 0.997) 50 1 CCC (P) CCC (P) CCC (P) CCC (P) CCC (P) CCC (P) CCC (P) CCC (P) : CCC CCC CCC CCC CCC CCC CCC (1.000) CTC CCC CCC CCC CCC CCC CCC (0.000) TCC CCC CCC CCC CCC CCC CCC (0.000) CCC CCC CCC CCC CCC CCC CCT (0.000) CAC CCC CCC CCC CCC CCC CCC (0.000) GCC CCC CCC CCC CCC CCC CCC (0.000) (total 1.000) 51 1 AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AAC (N) AGC (S) : AGC AAC AAC AAC AAC AAC AAC (0.730) AAC AAC AAC AAC AAC AAC AAC (0.269) ATC AAC AAC AAC AAC AAC AAC (0.001) AGC AAC AAC AAC AAC AAC AAT (0.000) ACC AAC AAC AAC AAC AAC AAC (0.000) AAC AAC AAC AAC AAC AAC AAT (0.000) (total 1.000) 52 1 ATC (I) ATC (I) ATC (I) ATC (I) ATC (I) ATC (I) ATC (I) ATC (I) : ATC ATC ATC ATC ATC ATC ATC (0.999) ATC ATC ATC ATC ATC ATC ATT (0.000) GTC ATC ATC ATC ATC ATC ATC (0.000) ACC ATC ATC ATC ATC ATC ATC (0.000) ATG ATC ATC ATC ATC ATC ATC (0.000) ATC ATC ATC ATT ATC ATC ATC (0.000) (total 1.000) 53 1 TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) TCC (S) ACC (T) : ACC TCC TCC TCC TCC TCC TCC (0.721) TCC TCC TCC TCC TCC TCC TCC (0.272) GCC TCC TCC TCC TCC TCC TCC (0.005) CCC TCC TCC TCC TCC TCC TCC (0.003) ATC TCC TCC TCC TCC TCC TCC (0.000) TTC TCC TCC TCC TCC TCC TCC (0.000) (total 1.000) 54 1 TTA (L) TTA (L) TTA (L) TTA (L) TTA (L) TTA (L) TTG (L) TTA (L) : TTA TTA TTA TTA TTA TTA TTA (0.929) TTA TTA TTA TTA TTA TTA TTG (0.069) TTA TTG TTG TTA TTA TTA TTG (0.001) TTA TTA TTA TTA TTA TTA CTA (0.000) TCA TTA TTA TTA TTA TTA TTA (0.000) GTA TTA TTA TTA TTA TTA TTA (0.000) (total 1.000) 55 1 CTG (L) CTG (L) CTG (L) CTG (L) TTG (L) TTG (L) TTG (L) CTG (L) : CTG CTG CTG CTG CTG CTG TTG (0.513) CTG TTG TTG CTG CTG CTG TTG (0.332) CTG CTG CTG CTG CTG CTG CTG (0.148) CTG TTG TTG TTG CTG CTG TTG (0.003) GTG TTG TTG CTG CTG CTG TTG (0.000) ATG TTG TTG CTG CTG CTG TTG (0.000) (total 0.997) 56 1 GAG (E) GAG (E) GAG (E) GAG (E) GAG (E) GAA (E) GAG (E) GAA (E) : GAA GAG GAG GAG GAG GAG GAG (0.684) GAA GAA GAA GAG GAG GAG GAA (0.218) GAA GAG GAG GAG GAG GAG GAA (0.072) GAA GAA GAA GAG GAG GAG GAG (0.020) AAA GAG GAG GAG GAG GAG GAG (0.000) GAC GAG GAG GAG GAG GAG GAG (0.000) (total 0.995) 57 1 GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) GGG (G) : GGG GGG GGG GGG GGG GGG GGG (0.998) GAG GGG GGG GGG GGG GGG GGG (0.001) GGG GGG GGG GGG GGG GGG GGA (0.000) AGG GGG GGG GGG GGG GGG GGG (0.000) GTG GGG GGG GGG GGG GGG GGG (0.000) GCG GGG GGG GGG GGG GGG GGG (0.000) (total 1.000) 58 1 AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) AAG (K) : AAG AAG AAG AAG AAG AAG AAG (0.995) AAG AAG AAG AAG AAG AAG AAA (0.002) GAG AAG AAG AAG AAG AAG AAG (0.001) AGG AAG AAG AAG AAG AAG AAG (0.001) AAG AAA AAA AAG AAG AAG AAG (0.000) AAG AAG AAG AAA AAG AAG AAG (0.000) (total 1.000) 59 1 GAA (E) GAA (E) GAA (E) GAA (E) GAG (E) GAA (E) GAA (E) GAG (E) : GAG GAA GAA GAA GAA GAA GAA (0.718) GAG GAG GAG GAA GAA GAA GAA (0.228) GAG GAG GAG GAA GAA GAA GAG (0.048) GAG GAG GAG GAG GAA GAA GAA (0.002) AAG GAA GAA GAA GAA GAA GAA (0.001) GGG GAA GAA GAA GAA GAA GAA (0.000) (total 0.996) 60 1 CCG (P) CCG (P) CCG (P) CCA (P) CCC (P) CCT (P) CCC (P) CCT (P) : CCT CCT CCT CCA CCG CCG CCT (0.339) CCT CCC CCC CCA CCG CCG CCC (0.252) CCT CCT CCT CCG CCG CCG CCT (0.203) CCT CCC CCC CCG CCG CCG CCC (0.151) CCC CCC CCC CCA CCG CCG CCC (0.000) CCC CCC CCC CCG CCG CCG CCC (0.000) (total 0.945) 61 1 GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) GTG (V) ATG (M) : ATG GTG GTG GTG GTG GTG GTG (0.726) GTG GTG GTG GTG GTG GTG GTG (0.266) ATG GTG GTG GTG GTG GTG GTA (0.002) TTG GTG GTG GTG GTG GTG GTG (0.001) GTG GTG GTG GTG GTG GTG GTA (0.001) CTG GTG GTG GTG GTG GTG GTG (0.001) (total 0.997) 62 1 GAG (E) GAG (E) GAG (E) GAG (E) CAA (Q) GAG (E) GAG (E) GAA (E) : GAA GAG GAG GAG GAG GAG GAG (0.431) GAA GAA GAA GAG GAG GAG GAG (0.422) GAA GAA GAA GAG GAG GAG GAA (0.134) GAA GAA GAA GAA GAG GAG GAG (0.006) AAA GAG GAG GAG GAG GAG GAG (0.000) AAA GAA GAA GAG GAG GAG GAG (0.000) (total 0.994) 63 1 AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AGA (R) AAA (K) AGA (R) : AGA AGA AGA AGA AGA AGA AGA (0.999) AGA AGA AGA AGA AGA AGA AGG (0.000) AAA AGA AGA AGA AGA AGA AGA (0.000) GGA AGA AGA AGA AGA AGA AGA (0.000) AGA AAA AGA AGA AGA AGA AAA (0.000) AAA AAA AGA AGA AGA AGA AAA (0.000) (total 1.000) 64 1 AAG (K) AAG (K) AAG (K) AAG (K) GAG (E) GAG (E) GAG (E) GAG (E) : GAG GAG GAG AAG AAG AAG GAG (0.979) GAG GAG AAG AAG AAG AAG GAG (0.015) GAG GAG GAG AAG AAG AAG GAA (0.003) AAG GAG GAG AAG AAG AAG GAG (0.001) GGG GAG GAG AAG AAG AAG GAG (0.001) GAG GAA GAA AAG AAG AAG GAG (0.000) (total 0.999) 65 1 ATG (M) ATG (M) ATG (M) ATG (M) CTG (L) ATG (M) ATG (M) ATA (I) : ATA ATG ATG ATG ATG ATG ATG (0.728) ATG ATG ATG ATG ATG ATG ATG (0.269) GTA ATG ATG ATG ATG ATG ATG (0.001) ATA ATG CTG ATG ATG ATG ATG (0.001) ATG ATG CTG ATG ATG ATG ATG (0.000) ACA ATG ATG ATG ATG ATG ATG (0.000) (total 0.999) 66 1 TCA (S) TCA (S) TCA (S) TCA (S) TCA (S) TCG (S) TCA (S) TCA (S) : TCA TCA TCA TCA TCA TCA TCA (0.971) TCA TCA TCA TCA TCA TCA TCG (0.029) TTA TCA TCA TCA TCA TCA TCA (0.000) TCA TCG TCG TCA TCA TCA TCG (0.000) CCA TCA TCA TCA TCA TCA TCA (0.000) TCA TCA TCA TCA TCA TCA TCC (0.000) (total 1.000) 67 1 CAG (Q) CAG (Q) CAG (Q) CAG (Q) CGT (R) GAT (D) GAT (D) GAT (D) : GAT GAT CAT CAG CAG CAG GAT (0.953) GAT GAT GAT CAG CAG CAG GAT (0.034) GAT GAT CAG CAG CAG CAG GAT (0.006) GAT GAT CGT CAG CAG CAG GAT (0.004) AAT GAT CAT CAG CAG CAG GAT (0.000) GGT GAT CAT CAG CAG CAG GAT (0.000) (total 0.998) List of extant and reconstructed sequences 15 243 hg18 ATG GCT GTG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG panTro2 ATG GCT ATG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG ponAbe2 ATG GCT GTG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG calJac1 ATG GCT GTG GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTA GCA CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC TTT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCA TGG ATG GTG GAG AGA AAG ATG TCA CAG cavPor3 ATG GCT GTT GGA CTT TGT AAA GAT ATG TCC CAG GGG TTG GTG ACT TTT AGA GAT GTG GCT CTA GAC TTT TCC CAA GAG GAG TGG GAA TGG CTT GCT CCG TCT CAG AAG GAT TTA TAC AGA GAA GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AAC ATG ATC TCC TTA TTG GAG CAA GGG AAG GAG CCC TGG ATG GTG CAA AGA GAG CTG TCA CGT bosTau4 ATG GCT GTT GGA CTC TGT AAA GCC ATG TCC CAG GGA TTG GTG ACC TTC AGG GAT GTA GCT CTG AAT TTT TCC CAA GAG GAA TGG GAA TGG CTG GAC TCA TCT CAG AAG GAT TTG TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA TTG GAA CAA GGG AAG GAA CCT TGG ATG GTG GAG AGA GAG ATG TCG GAT canFam2 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCT CAA GGT TTG GTG ACC TTC AGA GAT GTG GCT CTG GAT TTT TCT CAA GAG GAA TGG GAA TGG CTG GAT CCA TCT CAG AAG GAT TTA TAC AGA GAC GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTG TTG GAG CAA GGG AAG GAA CCC TGG ATG GTG GAG AAA GAG ATG TCA GAT dasNov2 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCT CAG GGG TTG GTG TCC TTC TGG GAT GTG GCT GTA GAC TTT TCT CAA GAG GAG TGG GAA TGG CTG GAT CCA TCT CAG AGG GAT TTA TAC AGA GAT GTC ACA TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AGC ATG ATC ACC TTA CTG GAA CAA GGG AAG GAG CCT TGG ATG ATG GAA AGA GAG ATA TCA GAT node #9 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCT CAG GGG TTG GTG TCC TTC TGG GAT GTG GCT GTA GAC TTT TCT CAA GAG GAG TGG GAA TGG CTG GAT CCA TCT CAG AGG GAT TTA TAC AGA GAT GTC ACA TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AGC ATG ATC ACC TTA CTG GAA CAA GGG AAG GAG CCT TGG ATG ATG GAA AGA GAG ATA TCA GAT node #10 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCT CTA GAC TTT TCC CAA GAG GAG TGG GAA TGG CTG GAT CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCT TGG ATG GTG GAG AGA GAG ATG TCA GAT node #11 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCT CTA GAC TTT TCC CAA GAG GAG TGG GAA TGG CTG GAT CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAA CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCT TGG ATG GTG GAG AGA GAG ATG TCA CAT node #12 ATG GCT GTG GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCA CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCA TGG ATG GTG GAG AGA AAG ATG TCA CAG node #13 ATG GCT GTG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG node #14 ATG GCT GTG GGG CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCG CTA GAC TTT TCC CAA GAA GAG TGG GAA TGG CTG AAG CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA CTG GAG CAA GGG AAG GAA CCG TGG ATG GTG GAG AGA AAG ATG TCA CAG node #15 ATG GCT GTT GGA CTT TGT AAA GCC ATG TCC CAG GGG TTG GTG ACC TTC AGA GAT GTG GCT CTG GAT TTT TCC CAA GAG GAA TGG GAA TGG CTG GAT CCA TCT CAG AAG GAT TTA TAC AGA GAT GTC ATG TTG GAG AAC TAC AGG AAC TTG GTA TGG CTT GGA CTC TCC ATT TCT AAG CCC AAC ATG ATC TCC TTA TTG GAG CAA GGG AAG GAA CCT TGG ATG GTG GAG AGA GAG ATG TCA GAT