ID ACT2_XENTR STANDARD; PRT; 377 AA. AC P20399; Q6GSH4; DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1991, sequence version 1. DT 25-JUL-2006, entry version 45. DE Actin, alpha sarcomeric/cardiac (Actin alpha 2). OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus; Silurana. OX NCBI_TaxID=8364; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Sarcomere; RX MEDLINE=88004409; PubMed=3653078; RA Stutz F., Spohr G.; RT "A processed gene coding for a sarcomeric actin in Xenopus laevis and RT Xenopus tropicalis."; RL EMBO J. 6:1989-1995(1987). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo; RG NIH - Xenopus Gene Collection (XGC) project; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Actins are highly conserved proteins that are involved CC in various types of cell motility and are ubiquitously expressed CC in all eukaryotic cells. CC -!- SUBUNIT: Polymerization of globular actin (G-actin) leads to a CC structural filament (F-actin) in the form of a two-stranded helix. CC Each actin can bind to 4 others. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- MISCELLANEOUS: In Xenopus, three different alpha actins have been CC identified, a single smooth muscle actin and two sarcomeric forms CC that are preferentially expressed either in the heart or in the CC skeletal muscle. Each of these three alpha actin genes is present CC in at least two copies. CC -!- SIMILARITY: Belongs to the actin family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; X05393; CAB43617.1; ALT_SEQ; Genomic_DNA. DR EMBL; BC064152; AAH64152.1; -; mRNA. DR PIR; B29686; B29686. DR UniGene; Str.20527; -. DR HSSP; P02568; 1IJJ. DR SMR; P20399; 6-373. DR Ensembl; ENSXETG00000021417; Xenopus tropicalis. DR InterPro; IPR004001; Actin. DR InterPro; IPR004000; Actin_like. DR PANTHER; PTHR11937; Actin_like; 1. DR Pfam; PF00022; Actin; 1. DR PRINTS; PR00190; ACTIN. DR SMART; SM00268; ACTIN; 1. DR PROSITE; PS00406; ACTINS_1; 1. DR PROSITE; PS00432; ACTINS_2; 1. DR PROSITE; PS01132; ACTINS_ACT_LIKE; 1. KW Acetylation; ATP-binding; Cytoskeleton; Muscle protein; KW Nucleotide-binding; Structural protein. FT PROPEP 1 2 Removed in mature form. FT /FTId=PRO_0000000824. FT CHAIN 3 377 Actin, alpha sarcomeric/cardiac. FT /FTId=PRO_0000000825. FT MOD_RES 3 3 N-acetylaspartate (in mature form) (By FT similarity). SQ SEQUENCE 377 AA; 42033 MW; E5C40FF19730CAD2 CRC64; MCDDEETTAL VCDNGSGLVK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH TFYNELRVAP EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIT KQEYDEAGPS IVHRKCF //